WormBase Tree Display for Gene: WBGene00003378
expand all nodes | collapse all nodes | view schema
| WBGene00003378 | Evidence | Person_evidence | WBPerson2322 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | T20B12 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | mml-1 | Person_evidence | WBPerson401 | |||||
| Sequence_name | T20B12.6 | ||||||||
| Molecular_name | T20B12.6a | ||||||||
| T20B12.6a.1 | |||||||||
| CE30186 | |||||||||
| T20B12.6b | |||||||||
| CE32727 | |||||||||
| T20B12.6b.1 | |||||||||
| Other_name | mio | Accession_evidence | EMBL | AF264757 | |||||
| CELE_T20B12.6 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | mml-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mml | ||||||||
| Allele (58) | |||||||||
| Strain | WBStrain00031665 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (24) | |||||||||
| Ortholog (41) | |||||||||
| Paralog | WBGene00001955 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00003510 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | mml-1 encodes, by alternative splicing, two isoforms of a bHLH-ZIP protein orthologous to human MLX (OMIM:602976), MLXIP (OMIM:608090), and MLXIPL (OMIM:605678, deleted in Williams-Beuren syndrome); MML-1 has five N-terminal Mondo Conserved Regions, an N-terminal nuclear localization sequence, and a C-terminal bHLHZip domain; with MXL-2, MML-1 is probably required for normal migration of ray 1 precursor cells in the male tail and for proper epidermal expression of extracellular matrix component genes; MML-1 is expressed in epidermal cells from 50-100 cell embryos onward, and in intestinal cells at the 4E stage, until adulthood; MML-1 requires MXL-2 for protein stability; MML-1 binds MXL-2 but not MXL-1 in two-hybrid assays; either coexpressed MML-1/MXL-2 or MML-1 alone can activate transcription via CACGTG E-boxes. | Paper_evidence | WBPaper00031002 | |||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 03 Feb 2008 00:00:00 | ||||||||
| Automated_description | Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in determination of adult lifespan and negative regulation of transcription by RNA polymerase II. Located in mitochondrion and nucleus. Expressed in excretory cell; hypodermis; intestine; and muscle cell. Is an ortholog of human MLXIP (MLX interacting protein) and MLXIPL (MLX interacting protein like). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:5844 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12744) | ||||
| DOID:3393 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12744) | ||||||
| Molecular_info | Corresponding_CDS | T20B12.6a | |||||||
| T20B12.6b | |||||||||
| Corresponding_transcript | T20B12.6a.1 | ||||||||
| T20B12.6b.1 | |||||||||
| Other_sequence (20) | |||||||||
| Associated_feature (11) | |||||||||
| Gene_product_binds (54) | |||||||||
| Transcription_factor | WBTranscriptionFactor001063 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00115787 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00005429 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00018880 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00035688 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00073277 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00071312 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00066962 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00053585 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00067454 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (11) | |||||||||
| Drives_construct | WBCnstr00012323 | ||||||||
| WBCnstr00015280 | |||||||||
| WBCnstr00015281 | |||||||||
| WBCnstr00016503 | |||||||||
| WBCnstr00019355 | |||||||||
| WBCnstr00023146 | |||||||||
| WBCnstr00036149 | |||||||||
| Construct_product | WBCnstr00012323 | ||||||||
| WBCnstr00016006 | |||||||||
| WBCnstr00016705 | |||||||||
| WBCnstr00019355 | |||||||||
| WBCnstr00021762 | |||||||||
| WBCnstr00023146 | |||||||||
| WBCnstr00036149 | |||||||||
| Regulate_expr_cluster | WBPaper00065993:mml-1(RNAi)-neuron_downregulated | ||||||||
| WBPaper00065993:mml-1(RNAi)-neuron_upregulated | |||||||||
| Antibody | WBAntibody00001297 | ||||||||
| Microarray_results (30) | |||||||||
| Expression_cluster (136) | |||||||||
| Interaction (47) | |||||||||
| Map_info | Map | III | Position | -0.747815 | Error | 0.001114 | |||
| Positive | Positive_clone | T20B12 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4452 | |||||||
| 5263 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (26) | |||||||||
| Remark | The locus mml-1 (Myc and Mondo-like 1) is based on a high level of sequence identity between mml-1 and its human orthologues, c-myc and MondoA | Person_evidence | WBPerson2322 | ||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
