WormBase Tree Display for Interaction: WBInteraction000520088
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| WBInteraction000520088 | Interaction_type | Regulatory | Change_of_expression_level | ||
|---|---|---|---|---|---|
| Interactor | Interactor_overlapping_gene | WBGene00015547 | Interactor_type | Trans_regulated | |
| Expr_pattern | Expr10992 | ||||
| Transgene | WBTransgene00018197 | ||||
| Construct | WBCnstr00017585 | ||||
| WBGene00012641 | Interactor_type | Trans_regulator | |||
| Variation_interactor | WBVar00597660 | Interactor_type | Trans_regulator | ||
| Interaction_summary | In wild-type embryos, AIN-1::GFP was diffusely expressed in the cytoplasm during embryogenesis. In autophagy mutants, including epg-6, atg-3, epg-8 and atg-2, AIN-1::GFP was strongly expressed and accumulated into a large number of aggregates. Levels of endogenous AIN-1 protein, but not ain-1 mRNA, were increased in autophagy mutants. These results indicate that AIN-1 is degraded by autophagy. | ||||
| Detection_method | Construct | ||||
| Reporter_gene | [ain-1::gfp] | ||||
| Transgene | |||||
| Regulation_level | Post_translational | ||||
| Regulation_result | Negative_regulate | Life_stage | WBls:0000003 | ||
| Subcellular_localization | cytoplasm | ||||
| Paper | WBPaper00042320 | ||||
| Remark | Loss of autophagy activity enhances let-7-mediated downregulation of target genes. |
