WormBase Tree Display for Gene: WBGene00015547
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| WBGene00015547 | SMap | S_parent | Sequence | C06G1 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | ain-1 | Person_evidence | WBPerson237 | |||||
| Sequence_name | C06G1.4 | ||||||||
| Molecular_name | C06G1.4 | ||||||||
| C06G1.4.1 | |||||||||
| CE03967 | |||||||||
| Other_name | CELE_C06G1.4 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | ain-1 | ||||||||
| DB_info | Database | AceView | gene | XR231 | |||||
| WormQTL | gene | WBGene00015547 | |||||||
| WormFlux | gene | WBGene00015547 | |||||||
| NDB | locus_tag | CELE_C06G1.4 | |||||||
| NCBI | gene | 181719 | |||||||
| RefSeq | protein | NM_078286.9 | |||||||
| TREEFAM | TREEFAM_ID | TF350152 | |||||||
| TrEMBL | UniProtAcc | Q17740 | |||||||
| UniProt_GCRP | UniProtAcc | Q17740 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:30:56 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 09 Sep 2005 11:28:41 | WBPerson2970 | Name_change | CGC_name | ain-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ain | ||||||||
| Allele (55) | |||||||||
| Strain | WBStrain00026530 | ||||||||
| WBStrain00026534 | |||||||||
| WBStrain00034970 | |||||||||
| WBStrain00054873 | |||||||||
| WBStrain00054872 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (22) | |||||||||
| Ortholog (26) | |||||||||
| Structured_description | Concise_description | ain-1 encodes an unfamiliar protein synergistically required, withLIN-31, for the normal timing of vulval differentiation, independentlyof LET-60/RAS, and parallel to or downstream of LIN-14/LIN-28/HBL-1;AIN-1 is expressed in cytoplasmic foci (that are probably P bodies) inseveral tissues, including vulval precursor cells and neurons; AIN-1coimmunoprecipitates with DCR-1 and ALG-1, also binds ALG-1 in vitro,and does not require DNA or RNA for its binding; in vivo, AIN-1 targetsALG-1 to cytoplasmic foci, in which it colocalizes with DCAP-2; AIN-1 islikely to be a RISC component, since anti-AIN-1 antibodies precipitate29 different miRNAs, including mir-2, mir-52, mir-58, mir-71, mir-77,and mir-239a; ain-1(ku322) mutants are essentially wild-type, except forsporadically gapped alae and excess seam cell nuclei arising fromretarded seam cell fusion; more prominently, ain-1(ku322) suppresses themultivulva phenotype of lin-31(n1053) mutations, while stronglyenhancing lin-31(n1053)'s egg-laying defect; the cellular basis oflin-31(n1053);ain-1(ku322) phenotypes is a delay in vulval developmentin L4 larvae not seen with either mutation alone; ain-1(ku322) has noeffect on let-60(n1046) or lin-3(e1275) mutations; ain-1(ku322)suppresses the precocious vulval development of lin-14(RNAi), lin-28mutants, and hbl-1(RNAi); alg-1 or alg-1 ain-1 mutant alae resembleain-1 alae, indicating that ALG-1 and AIN-1 act in a common geneticpathway; AIN-1 is homologous to Brugia malayi 14748.m00068,14052.m00191, and 14963.m01790, and paralogous to C. elegans B0041.2;AIN-1 and its nematode homologs have weak similarity to human TNRC6A(GW182; OMIM:610739) and Drosophila GAWKY. | Paper_evidence | WBPaper00026707 | |||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 07 May 2007 00:00:00 | ||||||||
| Automated_description | Involved in several processes, including embryo development; negative regulation of gene expression; and regulation of developmental process. Located in P-body. Expressed widely. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | C06G1.4 | |||||||
| Corresponding_CDS_history | C06G1.4:wp95 | ||||||||
| C06G1.4:wp99 | |||||||||
| Corresponding_transcript | C06G1.4.1 | ||||||||
| Other_sequence (15) | |||||||||
| Associated_feature (15) | |||||||||
| Experimental_info | RNAi_result (16) | ||||||||
| Expr_pattern (11) | |||||||||
| Drives_construct | WBCnstr00009448 | ||||||||
| WBCnstr00011571 | |||||||||
| WBCnstr00014500 | |||||||||
| WBCnstr00017585 | |||||||||
| WBCnstr00018660 | |||||||||
| WBCnstr00019818 | |||||||||
| WBCnstr00028761 | |||||||||
| WBCnstr00039524 | |||||||||
| Construct_product | WBCnstr00011571 | ||||||||
| WBCnstr00018660 | |||||||||
| WBCnstr00019818 | |||||||||
| WBCnstr00028761 | |||||||||
| WBCnstr00039524 | |||||||||
| Regulate_expr_cluster | WBPaper00031252:AIN-1_IP_enriched | ||||||||
| Antibody | WBAntibody00001341 | ||||||||
| WBAntibody00002435 | |||||||||
| WBAntibody00002673 | |||||||||
| WBAntibody00002711 | |||||||||
| Microarray_results (24) | |||||||||
| Expression_cluster (151) | |||||||||
| Interaction (458) | |||||||||
| Map_info | Map | X | Position | 24.0566 | Error | 0.000506 | |||
| Positive | Positive_clone | C06G1 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (40) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
