WormBase Tree Display for Interaction: WBInteraction000504989
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| WBInteraction000504989 | Interaction_type | Regulatory | Change_of_expression_level | ||
|---|---|---|---|---|---|
| Interactor | Interactor_overlapping_gene | WBGene00001580 | Interactor_type | Trans_regulator | |
| WBGene00003917 | Interactor_type | Trans_regulated | |||
| Expr_pattern | Expr2462 | ||||
| Interaction_summary | In wild-type embryos GFP::PAR-2 accumulated on the cortex of the posterior half of the embryo by the time of pronuclear meeting. By 150 s after pronuclear meeting GFP::PAR-2 was highly enriched at the posterior cortex, and reduced in the anterior cytoplasm. In contrast, loss of WAVE/SCAR or Arp2/3 components decreased GFP::PAR-2 accumulation at the posterior cortex. The earliest we could detect GFP::PAR-2 enrichment at the posterior cortex in mutants was at 300 s before pronuclear meeting, at levels below those seen in wild type.This defect in GFP::PAR-2 accumulation was fully penetrant, affecting 100% of gex-3 and arp-2 embryos examined. | ||||
| Detection_method | Reporter_gene | [par-2::gfp] | |||
| Regulation_result | Positive_regulate | Life_stage | WBls:0000003 | ||
| Subcellular_localization | posterior cortex | ||||
| Paper | WBPaper00039986 |
