WormBase Tree Display for Interaction: WBInteraction000504001
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| WBInteraction000504001 | Interaction_type | Regulatory | Change_of_expression_level | ||
|---|---|---|---|---|---|
| Interactor | Interactor_overlapping_gene | WBGene00004274 | Interactor_type | Trans_regulated | |
| Expr_pattern | Expr8340 | ||||
| Antibody | WBAntibody00001208 | ||||
| WBGene00001018 | Interactor_type | Trans_regulator | |||
| Interaction_summary | Depletion of DNC-2 led to GFPRAB- 11 loss from the pericentriolar region and the spindle. A clumping of GFP-RAB-11 was observed in the cytoplasm, particularly near the cortex. Endogenous RAB-11 localization was observed by immunostaining dnc-2(RNAi) embryos with anti-RAB-11 antibody. In these embryos, RAB-11 vesicles were dramatically diminished around centrosomes and along the spindle throughout the cell cycle. The fluorescence intensity around the centrosomes in dnc-2(RNAi) embryos was 70% less than that in wild-type embryos. | ||||
| Detection_method | Antibody | ||||
| Regulation_result | Positive_regulate | Subcellular_localization | centrosomes and slong the spindle | ||
| Paper | WBPaper00034709 |
