WormBase Tree Display for Interaction: WBInteraction000502656
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| WBInteraction000502656 | Interaction_type | Regulatory | Change_of_expression_level | ||
|---|---|---|---|---|---|
| Interactor | Interactor_overlapping_gene | WBGene00003914 | Interactor_type | Trans_regulator | |
| WBGene00004027 | Interactor_type | Trans_regulated | |||
| Expr_pattern | Expr574 | ||||
| Variation_interactor | WBVar00094709 | Interactor_type | Trans_regulator | ||
| WBVar00094734 | Interactor_type | Trans_regulator | |||
| Interaction_summary | During the one-cell stage in wild type, the transcription factor PIE-1 localized to the posterior and was found in the cytoplasm and nucleus of the P1 cell. In pam-1 embryos, PIE-1 failed to become properly partitioned during the first division, and was absent from both daughter cells in embryos that divided symmetrically. | ||||
| Detection_method | Reporter_gene | [pie-1::gfp], translational fusion | |||
| Regulation_level | Transcriptional | ||||
| Regulation_result | Positive_regulate | Life_stage | WBls:0000006 | ||
| WBls:0000007 | |||||
| Subcellular_localization | nucleus of P1 | ||||
| posterior cytoplasma | |||||
| Paper | WBPaper00028560 | ||||
| Remark | PAM-1 is necessary to promote proper segregation of developmental determinants along the AP axis during the first mitotic division. |
