WormBase Tree Display for Interaction: WBInteraction000502149
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| WBInteraction000502149 | Interaction_type | Regulatory | Change_of_expression_level | ||
|---|---|---|---|---|---|
| Interactor | Interactor_overlapping_gene | WBGene00018330 | Interactor_type | Trans_regulator | |
| WBGene00006750 | Interactor_type | Trans_regulated | |||
| Expr_pattern | Expr2418 | ||||
| Variation_interactor | WBVar00088133 | Interactor_type | Trans_regulator | ||
| Interaction_summary | Addition of the RIM C2A domain to the PDZ domain of RIM (GFP-PDZC2ARIM), but not the C2A domain of RIM alone (GFP-C2ARIM), was sufficient to localize RIM and restore ELKS localization. Interestingly, the localization of GFP-PDZC2ARIM is dependent on ELKS expression. | ||||
| Detection_method | Reporter_gene | [unc-10::gfp], translational fusion | |||
| Regulation_result | Positive_regulate | Anatomy_term | WBbt:0005829 | ||
| Paper | WBPaper00026618 | ||||
| Remark | ELKS plays a role, but not an essential role, in localizing RIM to the synapse. These data implicate another RIM-binding protein that interacts outside of the PDZ and C2A domains to aid in RIM localization to the synapse. |
