Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.

WormBase Tree Display for Gene: WBGene00006750

expand all nodes | collapse all nodes | view schema

Name Class

WBGene00006750SMapS_parentSequenceT10A3
IdentityVersion1
NameCGC_nameunc-10Person_evidenceWBPerson261
Sequence_nameT10A3.1
Molecular_name (18)
Other_namerim-1
RimPaper_evidenceWBPaper00013595
CELE_T10A3.1Accession_evidenceNDBBX284606
Public_nameunc-10
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:41WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classunc
Reference_alleleWBVar00142961
Allele (152)
Legacy_informatione102 : weak coiler tends to back loopy movement in reverse; fairly active slightly small and thin. ES3 ME2. NA2 (e126).
[C.elegansII] e102 : weak coiler, tends to back, loopy movement in reverse; fairly active; slightly small and thin; Ric. ES3 ME2. OA1: e126. [Brenner 1974; Nguyen et al. 1995]
[Nonet M] unc-10(e102) was phenotypically rescued by both cosmid C34H12 and a 16 kb BamHI/KpnI subclone of this cosmid that contains effectively only the rim-1 gene. The rim-1 gene (rim for Rab Interacting Molecule) is the combined genefinder products T10A3.1 and K03A1.3 (with several mistakes in the prediction by genefinder). Furthermore, unc-10(md330) and unc-10(md1117) both contain deletions of the vast majority of the rim-1 gene. Specifically, md1117 deleted 8.6 kb that extends from approximately 500 bp 5' of the atg to 200 bp 3' of the TAA of the rim-1 gene product.
[Nonet M] Encodes Rab-3 interacting protein.
StrainWBStrain00002752
WBStrain00027194
WBStrain00029061
WBStrain00004100
WBStrain00005485
WBStrain00005508
WBStrain00005509
WBStrain00051853
RNASeq_FPKM (74)
GO_annotation (32)
Ortholog (51)
Structured_descriptionConcise_descriptionunc-10 encodes a protein with zinc-finger, Q/N-rich, PDZ, and C2 domains that is homologous to vertebrate Rim1, a presynaptic protein which binds, and effects the activity of, synaptic vesicle-associated GTP-Rab3; UNC-10 is required for normal locomotion and synaptic transmission, and localizes to a subdomain of presynaptic termini, where it probably acts to regulate the priming step of presynaptic vesicle fusion by promoting conformational changes in syntaxin.Paper_evidenceWBPaper00002487
WBPaper00004891
WBPaper00005068
WBPaper00012788
WBPaper00012830
WBPaper00012882
WBPaper00012897
WBPaper00013003
Curator_confirmedWBPerson1843
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionEnables small GTPase binding activity. Involved in several processes, including chemical synaptic transmission; defecation; and positive regulation of cholinergic synaptic transmission. Located in axon and presynaptic active zone. Expressed in dorsal nerve cord; nerve ring; nervous system; uv1; and ventral nerve cord. Is an ortholog of human RIMS1 (regulating synaptic membrane exocytosis 1).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS290 version of WormBase
Date_last_updated11 Sep 2023 00:00:00
Molecular_infoCorresponding_CDST10A3.1a
T10A3.1b
T10A3.1c
T10A3.1d
T10A3.1e
T10A3.1f
Corresponding_transcriptT10A3.1a.1
T10A3.1b.1
T10A3.1c.1
T10A3.1d.1
T10A3.1e.1
T10A3.1f.1
Other_sequence (30)
Associated_feature (22)
Experimental_infoRNAi_result (19)
Expr_patternChronogram1591
Expr2418
Expr14780
Expr15235
Expr15236
Expr1017493
Expr1032824
Expr1156587
Expr2017837
Expr2035973
Drives_constructWBCnstr00003280
WBCnstr00034173
Construct_product (11)
AntibodyWBAntibody00000412
WBAntibody00000866
WBAntibody00001456
WBAntibody00001656
WBAntibody00001729
WBAntibody00002171
Microarray_results (30)
Expression_cluster (195)
Interaction (82)
Map_infoMapXPosition-1.7816Error0.001118
Well_ordered
PositivePositive_cloneC34H12
T10A3Person_evidenceWBPerson451
Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_data2_point147
182
3912
3913
6198
Multi_point (23)
Pos_neg_data (13)
Reference (107)
RemarkSequence connection from [Koushika SP, Nonet M]
Other name from JA Hodgkin, 09/02/2002
unc-10 is the same as rim-1 and therefore rim-1 was merged into unc-10 based on advice from JAH
MethodGene