WormBase Tree Display for Interaction: WBInteraction000501352
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| WBInteraction000501352 | Interaction_type | Genetic | Suppression | ||
|---|---|---|---|---|---|
| GI_module_two | Suppressing | ||||
| Interactor | Interactor_overlapping_gene | WBGene00004985 | Interactor_type | Effector | |
| WBGene00004297 | Interactor_type | Affected | |||
| Variation_interactor | WBVar00091464 | Interactor_type | Effector | ||
| Interaction_summary | In mature oocytes derived from F1 Unc animals that were heterozygous for the Ce-spo-11 mutation, depletion of Ce-rdh-1/rad-51 by RNAi was associated with the presence of aberrant chromosomes. In contrast, in mature oocytes derived from F1 animals (not Unc) that were homozygous for the Ce-spo-11 mutation and depleted for Ce-rdh-1/rad-51, twelve univalents were observed, which is the Ce-spo-11 mutant phenotype. These results indicate that the Ce-rdh-1/rad-51 RNAi effect is suppressed in the Ce-spo-11 mutant background. However, the twelve univalents in both defects of Ce-rdh-1/rad-51 and Ce-spo-11 could no longer be rescued by X-ray irradiation. Thus, the Ce-spo-11 mutation is epistatic to the Ce-rdh-1/rad-51 depletion, which interferes with homologous recombination after the generation of DSBs by both endogenous Ce-spo-11 and exogenous DNA lesion during meiosis. | ||||
| Throughput | Low_throughput | ||||
| Interaction_RNAi | WBRNAi00087468 | ||||
| Interaction_phenotype | WBPhenotype:0002013 | ||||
| Paper | WBPaper00005784 |
