WormBase Tree Display for Gene: WBGene00004985
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| WBGene00004985 | SMap | S_parent | Sequence | T05E11 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | spo-11 | Person_evidence | WBPerson1547 | |||||
| Sequence_name | T05E11.4 | ||||||||
| Molecular_name | T05E11.4a | ||||||||
| T05E11.4a.1 | |||||||||
| CE06363 | |||||||||
| T05E11.4b | |||||||||
| CE49824 | |||||||||
| T05E11.4b.1 | |||||||||
| Other_name | CELE_T05E11.4 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | spo-11 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:37 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | spo | ||||||||
| Allele (16) | |||||||||
| Legacy_information | [Dernburg AF] ok79 is 1227 bp deletion, presumed null. Homozygotes morphologically normal, Mel (>99%), Him, defective segregation of all chromosomes, meiotic exchange <1% of wildtype, normal synapsis of homologues. Encodes homologue of budding yeast Spo11p. | ||||||||
| Strain | WBStrain00034685 | ||||||||
| WBStrain00035158 | |||||||||
| WBStrain00035163 | |||||||||
| WBStrain00035164 | |||||||||
| WBStrain00000277 | |||||||||
| WBStrain00000282 | |||||||||
| WBStrain00007860 | |||||||||
| WBStrain00047223 | |||||||||
| WBStrain00047221 | |||||||||
| WBStrain00047220 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (23) | |||||||||
| Ortholog (36) | |||||||||
| Structured_description | Concise_description | spo-11 encodes an ortholog of Spo11p in S. cerevisiae that is required for meiotic DNA recombination, and (in conjunction with CHK-2 and MRE-11) for the localization of RAD-51 to foci in late zygotene/early pachytene nuclei; like its yeast ortholog, SPO-11 is related to a subunit of archaebacterial topoisomerase VI, and probably causes double-stranded DNA breaks through a topoisomerase-like transesterase mechanism; however, unlike Spo11p, SPO-11 is dispensable for homologous synapsis and formation of the synaptonemal complex; SPO-11 is active even in syp-1 mutants where its double-stranded breaks cannot be correctly processed; spo-11 is transcribed in the germline. | Paper_evidence | WBPaper00003166 | |||||
| WBPaper00005462 | |||||||||
| WBPaper00006010 | |||||||||
| WBPaper00012991 | |||||||||
| WBPaper00013229 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable DNA binding activity. Involved in meiotic DNA double-strand break processing. Predicted to be located in nuclear chromosome. Is an ortholog of human SPO11 (SPO11 initiator of meiotic double strand breaks). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | T05E11.4a | |||||||
| T05E11.4b | |||||||||
| Corresponding_transcript | T05E11.4a.1 | ||||||||
| T05E11.4b.1 | |||||||||
| Other_sequence | FD514501.1 | ||||||||
| JI175391.1 | |||||||||
| Dviv_isotig17985 | |||||||||
| CSC00934_1 | |||||||||
| Dviv_isotig17984 | |||||||||
| Associated_feature | WBsf652193 | ||||||||
| WBsf997770 | |||||||||
| WBsf1018175 | |||||||||
| WBsf230830 | |||||||||
| Experimental_info | RNAi_result (23) | ||||||||
| Expr_pattern | Expr1027139 | ||||||||
| Expr1032481 | |||||||||
| Expr1156137 | |||||||||
| Expr2016063 | |||||||||
| Expr2034299 | |||||||||
| Drives_construct | WBCnstr00035292 | ||||||||
| Construct_product | WBCnstr00035292 | ||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (117) | |||||||||
| Interaction (295) | |||||||||
| Map_info | Map | IV | Position | 4.89498 | Error | 0.004494 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | T05E11 | Person_evidence | WBPerson136 | |||||
| Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
| Mapping_data | Multi_point | 4609 | |||||||
| Reference (133) | |||||||||
| Remark | Data extracted from Dernburg et al. (1998) | ||||||||
| Method | Gene |
