WormBase Tree Display for Gene: WBGene00022492
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WBGene00022492 | SMap | S_parent | Sequence | Y119D3B | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | dss | ||||||
Allele (59) | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (26) | |||||||
Contained_in_operon | CEOP3060 | ||||||
Ortholog (26) | |||||||
Structured_description | Concise_description | dss-1 encodes the C. elegans ortholog of human DSS1 (deleted in split hand/split foot 1) and Saccharomyces cerevisiae SEM1, subunits of the 26S proteasome regulatory particle; in C. elegans, DSS-1 is an essential protein, required for oogenesis and for embryonic and larval development; in addition, dss-1 appears to be required for proper development and/or function of the intestine and dss-1 may play a role in vulval development and regulation of adult lifespan; although loss of dss-1 activity in C. elegans results in no obvious defects in proteasomal function, dss-1 expression in Saccharomyces cerevisiae can efficiently rescue Sem1 growth defects and partially rescue Sem1 protein degradation defects; a DSS-1::GFP fusion protein is expressed in the intestinal epithelium and head neurons during larval and adult stages; DSS-1::GFP expression is strongest in the nucleus, with more diffuse staining seen in the cytoplasm. | Paper_evidence | WBPaper00031869 | |||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 15 May 2008 00:00:00 | ||||||
Automated_description | Involved in several processes, including intestinal absorption; positive regulation of protein ubiquitination; and vulval development. Located in cytoplasm and nucleus. Expressed in head neurons. | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | Y119D3B.15 | |||||
Corresponding_CDS_history | Y119D3B.15:wp101 | ||||||
Corresponding_transcript | Y119D3B.15.1 | ||||||
Y119D3B.15.2 | |||||||
Other_sequence (61) | |||||||
Associated_feature | WBsf666558 | ||||||
WBsf226188 | |||||||
WBsf226189 | |||||||
Experimental_info | RNAi_result (12) | ||||||
Expr_pattern (7) | |||||||
Drives_construct | WBCnstr00013204 | ||||||
Construct_product | WBCnstr00013204 | ||||||
Microarray_results (19) | |||||||
Expression_cluster (88) | |||||||
Interaction (19) | |||||||
WBProcess | WBbiopr:00000001 | ||||||
Map_info | Map | III | Position | -22.6273 | Error | 0.006694 | |
Positive | Positive_clone | Y119D3B | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Pseudo_map_position | |||||||
Reference | WBPaper00027753 | ||||||
WBPaper00031869 | |||||||
WBPaper00033351 | |||||||
WBPaper00038491 | |||||||
WBPaper00041831 | |||||||
WBPaper00045116 | |||||||
WBPaper00055090 | |||||||
WBPaper00059748 | |||||||
WBPaper00061947 | |||||||
WBPaper00065621 | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |