WormBase Tree Display for Gene: WBGene00021348
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WBGene00021348 | SMap | S_parent | Sequence | Y37E3 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||||
Name | CGC_name | moag-4 | Person_evidence (2) | ||||||
Sequence_name | Y37E3.4 | ||||||||
Molecular_name | Y37E3.4 | ||||||||
Y37E3.4.1 | |||||||||
CE26771 | |||||||||
Other_name | CELE_Y37E3.4 | Accession_evidence | NDB | BX284601 | |||||
Public_name | moag-4 | ||||||||
DB_info | Database | AceView | gene | 1C633 | |||||
WormQTL | gene | WBGene00021348 | |||||||
WormFlux | gene | WBGene00021348 | |||||||
NDB | locus_tag | CELE_Y37E3.4 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00021348|UniProtKB=Q9BKU8 | |||||||
family | PTHR13596 | ||||||||
NCBI | gene | 171764 | |||||||
RefSeq | protein | NM_001393007.1 | |||||||
SwissProt | UniProtAcc | Q9BKU8 | |||||||
TREEFAM | TREEFAM_ID | TF330718 | |||||||
UniProt_GCRP | UniProtAcc | Q9BKU8 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 28 May 2004 13:31:04 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
2 | 23 Aug 2010 13:37:40 | WBPerson2970 | Name_change | CGC_name | moag-4 | ||||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | moag | ||||||||
Allele (18) | |||||||||
Strain (14) | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation | 00091687 | ||||||||
00091688 | |||||||||
00091689 | |||||||||
00091690 | |||||||||
00091691 | |||||||||
00091692 | |||||||||
00091693 | |||||||||
00091694 | |||||||||
Contained_in_operon | CEOP1028 | ||||||||
Ortholog (28) | |||||||||
Structured_description | Concise_description | moag-4 encodes a small protein that is evolutionarily highly conserved, containing a 4F5 domain predicted to have a helix-loop-helix secondary structure, moag-4 is orthologous to human SERF1A and SERF2 (OMIM: 603011, 605054); MOAG-4 is a general regulator of protein aggregation and proteotoxicity but it does not act on all disease-associated aggregation-prone proteins; MOAG-4 and human SERF proteins regulate polyglutamine aggregation in a similar manner; moag-4 acts cell autonomously on protein aggregation and presence of MOAG-4 drives aggregation-prone proteins toward a compact conformation preceding the formation of aggregates; MOAG-4 may drive aggregation by acting on soluble aggregation-prone proteins directly or by regulating a signaling pathway; MOAG-4 enhances aggregation either downstream or in parallel to hsf-1 and daf-16; presence of MOAG-4 enhances the toxicity of polyglutamine; MOAG::4Cherry is excluded from Polyglutamine aggregates. | Paper_evidence | WBPaper00037072 | |||||
Curator_confirmed | WBPerson12884 | ||||||||
WBPerson1843 | |||||||||
Date_last_updated | 15 Jun 2011 00:00:00 | ||||||||
Automated_description | Involved in protein destabilization. Located in cytosol and nucleus. Is an ortholog of human SERF2 (small EDRK-rich factor 2). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Molecular_info | Corresponding_CDS | Y37E3.4 | |||||||
Corresponding_transcript | Y37E3.4.1 | ||||||||
Other_sequence (80) | |||||||||
Associated_feature | WBsf643077 | ||||||||
WBsf656006 | |||||||||
WBsf217271 | |||||||||
Experimental_info | RNAi_result | WBRNAi00110185 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00055937 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern | Expr9106 | ||||||||
Expr1024902 | |||||||||
Expr1039316 | |||||||||
Expr1159455 | |||||||||
Expr2013636 | |||||||||
Expr2031870 | |||||||||
Drives_construct | WBCnstr00007435 | ||||||||
Construct_product (3) | |||||||||
Microarray_results (18) | |||||||||
Expression_cluster (90) | |||||||||
Interaction | WBInteraction000500420 | ||||||||
WBInteraction000500421 | |||||||||
WBInteraction000500423 | |||||||||
WBInteraction000500424 | |||||||||
WBInteraction000581211 | |||||||||
WBInteraction000582202 | |||||||||
Map_info | Map | I | Position | -12.1489 | Error | 0.033257 | |||
Positive | Positive_clone | Y37E3 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Pseudo_map_position | |||||||||
Reference | WBPaper00036362 | ||||||||
WBPaper00037072 | |||||||||
WBPaper00037461 | |||||||||
WBPaper00038491 | |||||||||
WBPaper00043673 | |||||||||
WBPaper00051480 | |||||||||
WBPaper00055090 | |||||||||
WBPaper00062006 | |||||||||
WBPaper00064185 | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |