WormBase Tree Display for Gene: WBGene00020442
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WBGene00020442 | SMap | S_parent | Sequence | T12A2 | |||
---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||
Name | CGC_name | gen-1 | Paper_evidence | WBPaper00036708 | |||
Person_evidence | WBPerson195 | ||||||
Sequence_name | T12A2.8 | ||||||
Molecular_name | T12A2.8 | ||||||
T12A2.8.1 | |||||||
CE01401 | |||||||
Other_name | CELE_T12A2.8 | Accession_evidence | NDB | BX284603 | |||
Public_name | gen-1 | ||||||
DB_info | Database | AceView | gene | 3H336 | |||
WormQTL | gene | WBGene00020442 | |||||
WormFlux | gene | WBGene00020442 | |||||
NDB | locus_tag | CELE_T12A2.8 | |||||
Panther | gene | CAEEL|WormBase=WBGene00020442|UniProtKB=Q22418 | |||||
family | PTHR11081 | ||||||
NCBI | gene | 175885 | |||||
RefSeq | protein | NM_065960.5 | |||||
TREEFAM | TREEFAM_ID | TF101235 | |||||
TrEMBL | UniProtAcc | Q22418 | |||||
UniProt_GCRP | UniProtAcc | Q22418 | |||||
Species | Caenorhabditis elegans | ||||||
History | Version_change (2) | ||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | gen | ||||||
Allele (42) | |||||||
Strain | WBStrain00034666 | ||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (18) | |||||||
Contained_in_operon | CEOP3360 | ||||||
Ortholog (22) | |||||||
Paralog | WBGene00000794 | Caenorhabditis elegans | From_analysis | Panther | |||
WormBase-Compara | |||||||
WBGene00009731 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00019004 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
Structured_description | Concise_description | gen-1 encodes the C. elegans homolog of the human GEN1 Holliday Junction resolving enzyme; in C. elegans, GEN-1 activity is required for DNA double-strand break repair and ionizing radiation-induced cell cycle arrest and apoptosis, independent of the CEP-1/p53 pathway, as part of a DNA damage signaling response; GEN-1 exhibits in vitro nuclease activity consistent with it functioning as a junction-resolving enzyme. | Paper_evidence | WBPaper00036708 | |||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 05 Jan 2012 00:00:00 | ||||||
Automated_description | Enables crossover junction DNA endonuclease activity. Involved in DNA damage response and negative regulation of nematode larval development. Predicted to be located in cytoplasm and nucleus. | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | T12A2.8 | |||||
Corresponding_transcript | T12A2.8.1 | ||||||
Other_sequence | CJC11994_1 | ||||||
CRC01733_1 | |||||||
Dviv_contig26186 | |||||||
Oden_isotig10028 | |||||||
Oden_isotig10029 | |||||||
CR04857 | |||||||
Oden_isotig10027 | |||||||
Associated_feature | WBsf651109 | ||||||
WBsf651110 | |||||||
WBsf976164 | |||||||
WBsf976165 | |||||||
WBsf992691 | |||||||
WBsf1015055 | |||||||
WBsf226791 | |||||||
WBsf226792 | |||||||
Experimental_info (8) | |||||||
Map_info | Map | III | Position | -1.40795 | Error | 9.2e-05 | |
Positive | Positive_clone | T12A2 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Pseudo_map_position | |||||||
Reference (12) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |