WormBase Tree Display for Gene: WBGene00019205
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| WBGene00019205 | SMap | S_parent | Sequence | CHROMOSOME_IV | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 4 | |||||||
| Name | CGC_name | kcc-2 | Person_evidence | WBPerson2369 | |||||
| WBPerson330 | |||||||||
| Sequence_name | H16O14.1 | ||||||||
| Molecular_name (15) | |||||||||
| Other_name | CELE_H16O14.1 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | kcc-2 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:01 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 02 Feb 2006 09:28:57 | WBPerson2970 | Name_change | CGC_name | kcc-3 | ||||
| 3 | 07 Jan 2008 15:15:28 | WBPerson2970 | Name_change | CGC_name | kcc-3 to kcc-2 | ||||
| 4 | 12 Oct 2009 09:37:24 | WBPerson1867 | Event | Acquires_merge | WBGene00019206 | ||||
| Acquires_merge | WBGene00019206 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | kcc | ||||||||
| Allele (373) | |||||||||
| Strain | WBStrain00026399 | ||||||||
| WBStrain00037336 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (20) | |||||||||
| Ortholog (67) | |||||||||
| Paralog | WBGene00006504 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00012543 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00015131 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00017350 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00019289 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00020207 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | kcc-2 encodes a potassium chloride cotransporter; in C. elegans, kcc-2 acts partially redundantly with the sodium-driven chloride-bicarbonate transporter, abts-1, for effecting GABA-receptor mediated inhibitory neurotransmission in the HSNs (hermaphrodite-specific neurons) that control egg-laying and in body wall muscle to control body length and movement; neuronal expression studies indicate that the regulation of abts-1 and kcc-2 is coordinated to control the cellular chloride gradient; kcc-2 is also required for normal synaptic development in the HSNs; KCC-2 shows chloride transporter activity in functional assays; KCC-2 is expressed in neurons and muscles. | Paper_evidence | WBPaper00035082 | |||||
| WBPaper00038249 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson324 | |||||||||
| Date_last_updated | 04 Apr 2011 00:00:00 | ||||||||
| Automated_description | Enables potassium:chloride symporter activity. Involved in chloride transport; potassium ion transport; and regulation of GABAergic synaptic transmission. Predicted to be located in plasma membrane. Expressed in body wall musculature; egg-laying apparatus; hermaphrodite distal tip cell; intestine; and neurons. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease; agenesis of the corpus callosum with peripheral neuropathy; and epilepsy (multiple). Is an ortholog of human SLC12A4 (solute carrier family 12 member 4); SLC12A5 (solute carrier family 12 member 5); and SLC12A7 (solute carrier family 12 member 7). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:10595 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10914) | ||||
| DOID:0090003 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10914) | ||||||
| DOID:0111315 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:13818) | ||||||
| DOID:0080460 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:13818) | ||||||
| Molecular_info | Corresponding_CDS | H16O14.1a | |||||||
| H16O14.1b | |||||||||
| H16O14.1c | |||||||||
| H16O14.1d | |||||||||
| H16O14.1e | |||||||||
| Corresponding_CDS_history | H16O14.1:wp183 | ||||||||
| H16O14.1:wp208 | |||||||||
| H16O14.1d:wp240 | |||||||||
| Corresponding_transcript | H16O14.1a.1 | ||||||||
| H16O14.1b.1 | |||||||||
| H16O14.1c.1 | |||||||||
| H16O14.1d.1 | |||||||||
| H16O14.1e.1 | |||||||||
| Other_sequence (45) | |||||||||
| Associated_feature (27) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00049419 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00049418 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr8769 | ||||||||
| Expr1027550 | |||||||||
| Expr1038293 | |||||||||
| Expr1153150 | |||||||||
| Expr2012911 | |||||||||
| Expr2031145 | |||||||||
| Drives_construct | WBCnstr00013507 | ||||||||
| WBCnstr00025991 | |||||||||
| Construct_product | WBCnstr00009656 | ||||||||
| WBCnstr00025991 | |||||||||
| Microarray_results (44) | |||||||||
| Expression_cluster (168) | |||||||||
| Interaction | WBInteraction000392849 | ||||||||
| WBInteraction000468547 | |||||||||
| WBInteraction000501231 | |||||||||
| WBInteraction000504780 | |||||||||
| WBInteraction000517363 | |||||||||
| WBInteraction000517364 | |||||||||
| WBInteraction000517365 | |||||||||
| Map_info | Map | IV | Position | 2.94997 | Error | 0.001251 | |||
| Positive | Positive_clone | H16O14 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (13) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
