WormBase Tree Display for Gene: WBGene00013261

WBGene00013261 SMap: S_parent: Sequence: Y57A10A
  Identity: Version: 3
    Name: CGC_name: sinh-1 Person_evidence: WBPerson1157
      Sequence_name: Y57A10A.20
      Molecular_name: Y57A10A.20
        Y57A10A.20.1
        CE43373
      Other_name: CeSRm300
        CELE_Y57A10A.20 Accession_evidence: NDB BX284602
      Public_name: sinh-1
    DB_info: Database: AceView gene 2M523
        WormQTL gene WBGene00013261
        WormFlux gene WBGene00013261
        NDB locus_tag CELE_Y57A10A.20
        Panther gene CAEEL|WormBase=WBGene00013261|UniProtKB=Q9NA80
          family PTHR13335
        NCBI gene 190339
        RefSeq protein NM_064195.5
        SwissProt UniProtAcc Q9NA80
        TREEFAM TREEFAM_ID TF315174
        UniProt_GCRP UniProtAcc Q9NA80
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:54 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 31 Aug 2005 14:07:05 WBPerson2970 Name_change: CGC_name: sinh-1
        3 27 Nov 2008 12:07:14 WBPerson1983 Event: Acquires_merge: WBGene00004707
      Acquires_merge: WBGene00004707
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: sinh
    Allele (446)
    Strain: WBStrain00022702
    RNASeq_FPKM (74)
    GO_annotation: 00095845
      00095846
      00095847
      00095848
      00095849
      00095850
      00120159
    Contained_in_operon: CEOP2720
    Ortholog (33)
    Structured_description: Concise_description: sinh-1 encodes the C. elegans ortholog of mammalian SIN1, an essential component of the TORC2 complex that plays a key role in Akt phosphorylation and signaling; in C. elegans, loss of sinh-1 activity via RNAi results in enhanced dauer formation, increased thermotolerance, enhanced stress response, and daf-16-dependent lifespan extension. Paper_evidence: WBPaper00026715
            WBPaper00031306
          Curator_confirmed: WBPerson1843
          Date_last_updated: 14 Dec 2007 00:00:00
      Automated_description: Predicted to enable phosphatidylinositol-4,5-bisphosphate binding activity. Involved in mesendoderm development. Predicted to be located in cytoplasm and plasma membrane. Predicted to be part of TORC2 complex. Is an ortholog of human MAPKAP1 (MAPK associated protein 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: Y57A10A.20
    Corresponding_CDS_history: Y57A10A.20:wp109
      Y57A10A.20:wp197
    Corresponding_transcript: Y57A10A.20.1
    Other_sequence (13)
    Associated_feature: WBsf990040
      WBsf222250
      WBsf222251
  Experimental_info: RNAi_result: WBRNAi00057624 Inferred_automatically: RNAi_primary
      WBRNAi00078073 Inferred_automatically: RNAi_primary
      WBRNAi00057623 Inferred_automatically: RNAi_primary
      WBRNAi00064002 Inferred_automatically: RNAi_primary
      WBRNAi00037561 Inferred_automatically: RNAi_primary
      WBRNAi00021098 Inferred_automatically: RNAi_primary
      WBRNAi00021099 Inferred_automatically: RNAi_primary
      WBRNAi00080806 Inferred_automatically: RNAi_primary
      WBRNAi00057622 Inferred_automatically: RNAi_primary
      WBRNAi00064001 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1019426
      Expr1035917
      Expr1161034
      Expr2015820
      Expr2034053
    Microarray_results (39)
    Expression_cluster (91)
  Map_info: Map: II Position: 7.18801 Error: 0.042357
    Positive: Positive_clone: Y57A10A Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00005023
    WBPaper00026715
    WBPaper00033162
    WBPaper00037861
    WBPaper00038491
    WBPaper00044096
    WBPaper00051289
    WBPaper00052584
    WBPaper00055090
    WBPaper00066161
  Remark: Y57A10A.21 (WBGene00004707) was connected to rsr-2 based on published data, but rsr-2 is Y57A10A.19 (WBGene00013260). Paper_evidence: WBPaper00005023
      Curator_confirmed: WBPerson2970
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene