WormBase Tree Display for Gene: WBGene00008117
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| WBGene00008117 | SMap | S_parent | Sequence | C46F11 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | gsr-1 | Person_evidence | WBPerson664 | |||||
| Sequence_name | C46F11.2 | ||||||||
| Molecular_name | C46F11.2a | ||||||||
| C46F11.2a.1 | |||||||||
| CE17558 | |||||||||
| C46F11.2b | |||||||||
| CE08773 | |||||||||
| C46F11.2b.1 | |||||||||
| C46F11.2b.2 | |||||||||
| Other_name | CELE_C46F11.2 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | gsr-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:48 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 26 Mar 2010 16:30:18 | WBPerson2970 | Name_change | CGC_name | gsr-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | gsr | ||||||||
| Allele (35) | |||||||||
| Strain | WBStrain00001618 | ||||||||
| WBStrain00040328 | |||||||||
| WBStrain00051074 | |||||||||
| WBStrain00051072 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (31) | |||||||||
| Ortholog (35) | |||||||||
| Paralog | WBGene00006937 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
| WBGene00007744 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00010794 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00014028 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00015553 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00017640 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | gsr-1 encodes a glutathionine reductase orthologous to human mitochondrial glutathione reductase (GSR; OMIM:138300); GSR deficiency has been associated with hemolytic anemia; loss of gsr-1 activity, together with that of trxr-1, results in molting defects characterized by a failure to remove old cuticle and reduced, disulfide groups in the cuticle that remain oxidized; gsr-1 expression is reduced in dauer larvae. | Paper_evidence | WBPaper00037973 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 28 May 2014 00:00:00 | ||||||||
| Automated_description | Enables glutathione-disulfide reductase (NADP) activity. Involved in several processes, including cell redox homeostasis; ecdysis, collagen and cuticulin-based cuticle; and response to superoxide. Located in cytosol and mitochondrion. Expressed in several structures, including Epr; Epra; coelomocyte; excretory canal; and hermaphrodite gonad. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; cataract (multiple); hematologic cancer (multiple); and hemolytic anemia (multiple). Is an ortholog of human GSR (glutathione-disulfide reductase). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (21) | ||||||||
| Molecular_info | Corresponding_CDS | C46F11.2a | |||||||
| C46F11.2b | |||||||||
| Corresponding_transcript | C46F11.2a.1 | ||||||||
| C46F11.2b.1 | |||||||||
| C46F11.2b.2 | |||||||||
| Other_sequence (76) | |||||||||
| Associated_feature | WBsf645036 | ||||||||
| WBsf658761 | |||||||||
| WBsf224635 | |||||||||
| WBsf224636 | |||||||||
| Experimental_info | RNAi_result (20) | ||||||||
| Expr_pattern (14) | |||||||||
| Drives_construct (11) | |||||||||
| Construct_product | WBCnstr00017629 | ||||||||
| WBCnstr00023131 | |||||||||
| WBCnstr00023132 | |||||||||
| WBCnstr00023133 | |||||||||
| WBCnstr00023134 | |||||||||
| WBCnstr00023135 | |||||||||
| WBCnstr00023136 | |||||||||
| Microarray_results (28) | |||||||||
| Expression_cluster (119) | |||||||||
| Interaction (88) | |||||||||
| Map_info | Map | III | Position | -4.91444 | Error | 0.040413 | |||
| Positive | Positive_clone | C46F11 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00035663 | ||||||||
| WBPaper00037973 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00041408 | |||||||||
| WBPaper00042271 | |||||||||
| WBPaper00049591 | |||||||||
| WBPaper00054822 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00056248 | |||||||||
| WBPaper00060669 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
