WormBase Tree Display for Gene: WBGene00007561
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| WBGene00007561 | SMap | S_parent | Sequence | C14A4 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | ccm-3 | Person_evidence | WBPerson137 | |||||
| Sequence_name | C14A4.11 | ||||||||
| Molecular_name | C14A4.11 | ||||||||
| C14A4.11.1 | |||||||||
| CE30598 | |||||||||
| Other_name | CELE_C14A4.11 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | ccm-3 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:48 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 10 Jul 2013 10:45:28 | WBPerson2970 | Name_change | CGC_name | ccm-3 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ccm | ||||||||
| Allele (29) | |||||||||
| Strain | WBStrain00035264 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (21) | |||||||||
| Contained_in_operon | CEOP2693 | ||||||||
| CEOP2704 | |||||||||
| Ortholog (36) | |||||||||
| Structured_description | Concise_description | ccm-3 encodes a protein with similarity to vertebrate programmed cell death protein 10, also known as TFAR15 or CCM3, which is associated with cerebral cavernous malformations type 3 (OMIM:603285); in C. elegans, deletion mutations in ccm-3 are associated with sterility and lethality and large-scale RNAi experiments targeting ccm-3 result in embryonic lethality, body morphology defects, and maternal sterility; large-scale expression studies show that ccm-3 is widely expressed from mid-embryogenesis onward, with consistent expression seen in the intestine and the vulva. | Paper_evidence | WBPaper00005654 | |||||
| WBPaper00025054 | |||||||||
| WBPaper00029055 | |||||||||
| WBPaper00031006 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 14 Oct 2013 00:00:00 | ||||||||
| Automated_description | Enables protein kinase binding activity. Involved in several processes, including endoplasmic reticulum organization; positive regulation of endocytic recycling; and regulation of Golgi organization. Located in cytoplasm; cytoplasmic side of apical plasma membrane; and growing cell tip. Expressed in several structures, including excretory canal; germ line; intestinal cell; oocyte; and pharynx. Used to study cerebral cavernous malformation. Human ortholog(s) of this gene implicated in cerebral cavernous malformation 3. Is an ortholog of human PDCD10 (programmed cell death 10). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:0060669 | Homo sapiens | Paper_evidence | WBPaper00046519 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 24 Sep 2020 00:00:00 | ||||||||
| Potential_model | DOID:2870 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8761) | |||||
| DOID:5082 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8761) | ||||||
| DOID:0060671 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8761) | ||||||
| DOID:686 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8761) | ||||||
| DOID:2237 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8761) | ||||||
| Models_disease_asserted | WBDOannot00000809 | ||||||||
| Molecular_info | Corresponding_CDS | C14A4.11 | |||||||
| Corresponding_CDS_history | C14A4.11:wp78 | ||||||||
| Corresponding_transcript | C14A4.11.1 | ||||||||
| Other_sequence (26) | |||||||||
| Associated_feature | WBsf650513 | ||||||||
| WBsf989409 | |||||||||
| WBsf223822 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00040467 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00112506 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00033323 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00085594 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00008387 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00111621 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (13) | |||||||||
| Drives_construct | WBCnstr00001054 | ||||||||
| WBCnstr00003302 | |||||||||
| WBCnstr00012578 | |||||||||
| WBCnstr00033644 | |||||||||
| WBCnstr00042003 | |||||||||
| Construct_product | WBCnstr00020249 | ||||||||
| WBCnstr00033644 | |||||||||
| WBCnstr00042003 | |||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (106) | |||||||||
| Interaction (23) | |||||||||
| Map_info | Map | II | Position | 3.12113 | |||||
| Positive | Positive_clone | C14A4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (21) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
