WormBase Tree Display for Gene: WBGene00007054
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WBGene00007054 | SMap | S_parent | Sequence | B0379 | |||
---|---|---|---|---|---|---|---|
Identity | Version | 3 | |||||
Name | CGC_name | scpl-1 | Person_evidence | WBPerson56 | |||
Sequence_name | B0379.4 | ||||||
Molecular_name | B0379.4a | ||||||
B0379.4a.1 | |||||||
CE34243 | |||||||
B0379.4b | |||||||
CE34244 | |||||||
B0379.4c | |||||||
CE41191 | |||||||
B0379.4b.1 | |||||||
B0379.4c.1 | |||||||
Other_name (2) | |||||||
Public_name | scpl-1 | ||||||
DB_info | Database (12) | ||||||
Species | Caenorhabditis elegans | ||||||
History (2) | |||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | scpl | ||||||
Allele (181) | |||||||
Strain | WBStrain00031805 | ||||||
WBStrain00035918 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (22) | |||||||
Ortholog (45) | |||||||
Paralog | WBGene00021629 | Caenorhabditis elegans | From_analysis | Panther | |||
WormBase-Compara | |||||||
WBGene00011897 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00018474 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
Structured_description | Concise_description | scpl-1 encodes, by alternative splicing, two protein isoforms of a putative class-C RNA polymerase II (RNAPII) carboxyl-terminal domain (CTD) phosphatase, orthologous to budding yeast PSR1 and PSR2 and human CTDSP1 (OMIM:605323), CTDSP2 (OMIM:608711, amplified in sarcoma), and CTDSPL (OMIM:608592, deleted in epithelial cancer), and paralogous to C. elegans SCPL-3 and human CTDSPL2; more distantly, SCPL-1 (and its paralog SCPL-3) are similar to SCPL-2, SCPL-4, and FCP-1; loss of scpl-1 activity via RNAi results in a slightly abnormal egg-laying response in the presence of serotonin; an scpl-1::gfp promoter fusion is expressed in pharyngeal, vulval, and body wall muscle; within body wall muscle, SCPL-1 localize to the M line and I band; SCPL-1 physically interacts with UNC-89 both in vitro and in vivo. | Paper_evidence | WBPaper00029277 | |||
WBPaper00029278 | |||||||
WBPaper00029279 | |||||||
WBPaper00029280 | |||||||
WBPaper00031595 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson567 | |||||||
Date_last_updated | 16 Dec 2011 00:00:00 | ||||||
Automated_description | Enables several functions, including LIM domain binding activity; kinase binding activity; and protein-macromolecule adaptor activity. Involved in dephosphorylation and regulation of egg-laying behavior. Located in I band and M band. Expressed in body wall musculature; pharyngeal muscle cell; and vulval muscle. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Is an ortholog of human CTDSP1 (CTD small phosphatase 1) and CTDSPL (CTD small phosphatase like). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:3908 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:16890) | ||
Molecular_info | Corresponding_CDS | B0379.4a | |||||
B0379.4b | |||||||
B0379.4c | |||||||
Corresponding_CDS_history | B0379.4:wp77 | ||||||
B0379.4a:wp103 | |||||||
B0379.4b:wp103 | |||||||
Corresponding_transcript | B0379.4a.1 | ||||||
B0379.4b.1 | |||||||
B0379.4c.1 | |||||||
Other_sequence (38) | |||||||
Associated_feature (22) | |||||||
Transcription_factor | WBTranscriptionFactor000636 | ||||||
Experimental_info | RNAi_result (13) | ||||||
Expr_pattern | Chronogram589 | ||||||
Expr8052 | |||||||
Expr8053 | |||||||
Expr1015780 | |||||||
Expr1033029 | |||||||
Expr1143160 | |||||||
Expr2015647 | |||||||
Expr2033879 | |||||||
Drives_construct | WBCnstr00002821 | ||||||
WBCnstr00013080 | |||||||
Antibody | WBAntibody00001386 | ||||||
WBAntibody00001387 | |||||||
Microarray_results (25) | |||||||
Expression_cluster (94) | |||||||
Interaction (39) | |||||||
Map_info | Map | I | Position | 4.63311 | Error | 0.019017 | |
Positive | Positive_clone | B0379 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | Multi_point | 5541 | |||||
5251 | |||||||
Pseudo_map_position | |||||||
Reference (11) | |||||||
Remark | tag-188 is parsed from CGC strain VC612 | ||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||
Method | Gene |