WormBase Tree Display for Gene: WBGene00006655
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| WBGene00006655 | SMap | S_parent | Sequence | F10B5 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | tub-1 | Person_evidence | WBPerson1122 | |||||
| Sequence_name | F10B5.4 | ||||||||
| Molecular_name | F10B5.4 | ||||||||
| F10B5.4.1 | |||||||||
| CE29091 | |||||||||
| Other_name | CELE_F10B5.4 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | tub-1 | ||||||||
| DB_info | Database | AceView | gene | 2I446 | |||||
| WormQTL | gene | WBGene00006655 | |||||||
| WormFlux | gene | WBGene00006655 | |||||||
| OMIM | disease | 203750 | |||||||
| 601665 | |||||||||
| gene | 602280 | ||||||||
| NDB | locus_tag | CELE_F10B5.4 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006655|UniProtKB=Q09306 | |||||||
| family | PTHR16517 | ||||||||
| NCBI | gene | 174312 | |||||||
| RefSeq | protein | NM_063309.5 | |||||||
| SwissProt | UniProtAcc | Q09306 | |||||||
| UniProt_GCRP | UniProtAcc | Q09306 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:41 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | tub | ||||||||
| Allele (29) | |||||||||
| Legacy_information | [Basson M] tub for homolog of mouse TUBby gene (mutant mice become obese, blind, deaf). Deletion mutants of entire ORF obtained. Predicted gene F10B4.4 | ||||||||
| Strain (11) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (20) | |||||||||
| Ortholog (46) | |||||||||
| Paralog | WBGene00016935 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00022139 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | tub-1 encodes a TUBBY homolog that affects fat storage across species including C. elegans; tub-1 functions with kat-1, a 3-ketoacyl-coA thiolase, to affect lipid accumulation; tub-1 is also required for normal life span as tub-1 mutants show extended life span which is dependent on daf-16/FOXO3a; tub-1 interacts with a novel RabGTPase-activating protein RBG-3 and upregulates the activity of a small GTPase, RAB-7, suggesting the involvement of an endocytic pathway in regulating fat storage; tub-1 is expressed in ciliated neurons where its activity is required for proper localization of G protein-coupled receptors to nonmotile primary cilia; tub-1 localizes predominantly to the cytoplasm, but undergoes transport supporting its involvement in neuronal trafficking and chemosensation. | Paper_evidence | WBPaper00005655 | |||||
| WBPaper00018838 | |||||||||
| WBPaper00026699 | |||||||||
| WBPaper00030935 | |||||||||
| WBPaper00044991 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| WBPerson1843 | |||||||||
| WBPerson324 | |||||||||
| Date_last_updated | 18 Apr 2014 00:00:00 | ||||||||
| Automated_description | Involved in positive regulation of neurogenesis and receptor localization to non-motile cilium. Located in cytoplasm; non-motile cilium; and periciliary membrane compartment. Expressed in neurons. Used to study obesity. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 15; obesity; and retinitis pigmentosa 14. Is an ortholog of human TUB (TUB bipartite transcription factor); TULP1 (TUB like protein 1); and TULP3 (TUB like protein 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:9970 | Homo sapiens | Paper_evidence | WBPaper00026699 | ||||
| Accession_evidence | OMIM | 601665 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 06 Oct 2017 00:00:00 | ||||||||
| Potential_model | DOID:0110381 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12423) | |||||
| DOID:0110189 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12423) | ||||||
| DOID:9970 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12406) | ||||||
| DOID:10584 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12423) | ||||||
| Disease_relevance | tub-1/tubby is a gene involved in obesity across species; studies in C. elegans indicate that: decreased kat-1 (a ketoacyl-coA thiolase involved in fatty acid oxidation) activity appears to be responsible for increased fat accumulation in tub-1/Tubby worms; further, mutations causing alterations in ciliated neurogenesis mimic the genetic interaction of kat-1 and tub-1, suggesting the involvement of neurohormonal mechanisms in the regulation of lipid accumulation; a tub-1-mediated endocytic pathway may also be involved in regulation of fat storage, as indicated by interactions of tub-1 with the Rab-GTPase-activating protein RBG-3 and the small Rab-GTPase, RAB-7. | Homo sapiens | Paper_evidence | WBPaper00031329 | |||||
| WBPaper00038405 | |||||||||
| Accession_evidence | OMIM | 203750 | |||||||
| 601665 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 13 Jan 2012 00:00:00 | ||||||||
| Models_disease_asserted | WBDOannot00000027 | ||||||||
| WBDOannot00000029 | |||||||||
| WBDOannot00000444 | |||||||||
| Molecular_info | Corresponding_CDS | F10B5.4 | |||||||
| Corresponding_transcript | F10B5.4.1 | ||||||||
| Other_sequence (20) | |||||||||
| Associated_feature | WBsf650298 | ||||||||
| WBsf665772 | |||||||||
| WBsf988665 | |||||||||
| WBsf1012655 | |||||||||
| WBsf223450 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00044210 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00112691 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00075849 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00013034 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00027884 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr3486 | ||||||||
| Expr3658 | |||||||||
| Expr10125 | |||||||||
| Expr14820 | |||||||||
| Expr14821 | |||||||||
| Expr1013504 | |||||||||
| Expr1032765 | |||||||||
| Expr1148169 | |||||||||
| Expr2017632 | |||||||||
| Expr2035772 | |||||||||
| Drives_construct | WBCnstr00000350 | ||||||||
| WBCnstr00000974 | |||||||||
| WBCnstr00000975 | |||||||||
| WBCnstr00000976 | |||||||||
| WBCnstr00011419 | |||||||||
| WBCnstr00011578 | |||||||||
| WBCnstr00016027 | |||||||||
| WBCnstr00016028 | |||||||||
| WBCnstr00034237 | |||||||||
| Construct_product | WBCnstr00001288 | ||||||||
| WBCnstr00001289 | |||||||||
| WBCnstr00011578 | |||||||||
| WBCnstr00034237 | |||||||||
| WBCnstr00041433 | |||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (120) | |||||||||
| Interaction (29) | |||||||||
| WBProcess | WBbiopr:00000121 | ||||||||
| Map_info | Map | II | Position | 0.71455 | Error | 0.002369 | |||
| Positive | Positive_clone | F10B4 | Author_evidence | (genome sequence, | |||||
| F10B5 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | Multi_point | 5502 | |||||||
| 5061 | |||||||||
| 5088 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (41) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
