WormBase Tree Display for Gene: WBGene00006405
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| WBGene00006405 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | Y116A8C | ||||||
| Identity | Version | 2 | |||||||
| Name | CGC_name | itsn-1 | Person_evidence | WBPerson1422 | |||||
| Sequence_name | Y116A8C.36 | ||||||||
| Molecular_name (18) | |||||||||
| Other_name | tag-11 | Curator_confirmed | WBPerson2970 | ||||||
| CELE_Y116A8C.36 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | itsn-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:40 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 18 Feb 2005 12:07:44 | WBPerson2970 | Name_change | CGC_name | itsn-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | itsn | ||||||||
| Allele (138) | |||||||||
| Strain | WBStrain00035580 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (15) | |||||||||
| Ortholog (46) | |||||||||
| Paralog | WBGene00001224 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
| WBGene00004373 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | itsn-1 encodes an EF hand and SH3 domain-containing protein that is homologous to the vertebrate and Drosophila intersectins; ITSN-1 functions as an endocytic adaptor protein to regulate cargo sorting through the endolysosomal system; ITSN-1 is also required, together with EHS-1, for synaptic vesicle recycling and hence, regulation of neurotransmission; in addition, ITSN-1 appears to function redundantly with DAB-1 for normal growth and development; immunofluorescence staining of embryos indicates that FCHO-1 localizes to the plasma membrane and additionally, an ITSN-1::GFP fusion protein colocalizes to synaptic vesicles. | Paper_evidence | WBPaper00004103 | |||||
| WBPaper00031112 | |||||||||
| WBPaper00031546 | |||||||||
| WBPaper00042550 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 19 Sep 2013 00:00:00 | ||||||||
| Automated_description | Predicted to enable molecular adaptor activity. Involved in positive regulation of synaptic vesicle endocytosis. Located in endocytic vesicle and presynaptic periactive zone. Expressed in neurons; somatic nervous system; tail; and vulva. Is an ortholog of human ITSN2 (intersectin 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | Y116A8C.36a | |||||||
| Y116A8C.36b | |||||||||
| Y116A8C.36c | |||||||||
| Y116A8C.36d | |||||||||
| Y116A8C.36e | |||||||||
| Y116A8C.36f | |||||||||
| Corresponding_CDS_history | Y116A8C.36:wp191 | ||||||||
| Corresponding_transcript | Y116A8C.36a.1 | ||||||||
| Y116A8C.36b.1 | |||||||||
| Y116A8C.36c.1 | |||||||||
| Y116A8C.36d.1 | |||||||||
| Y116A8C.36e.1 | |||||||||
| Y116A8C.36f.1 | |||||||||
| Other_sequence (41) | |||||||||
| Associated_feature | WBsf660976 | ||||||||
| WBsf660977 | |||||||||
| WBsf977053 | |||||||||
| WBsf977054 | |||||||||
| WBsf1018952 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00019928 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00075455 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00098505 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00055454 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00061915 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00036612 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00075454 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (14) | |||||||||
| Drives_construct | WBCnstr00004981 | ||||||||
| WBCnstr00004982 | |||||||||
| WBCnstr00013062 | |||||||||
| WBCnstr00013063 | |||||||||
| WBCnstr00013064 | |||||||||
| WBCnstr00013065 | |||||||||
| Construct_product | WBCnstr00005443 | ||||||||
| WBCnstr00013064 | |||||||||
| WBCnstr00013065 | |||||||||
| Antibody | WBAntibody00001316 | ||||||||
| WBAntibody00001378 | |||||||||
| WBAntibody00002465 | |||||||||
| Microarray_results (23) | |||||||||
| Expression_cluster (120) | |||||||||
| Interaction (214) | |||||||||
| Map_info | Map | IV | Position | 16.2075 | Error | 0.004115 | |||
| Positive | Positive_clone | Y116A8C | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4164 | |||||||
| Pseudo_map_position | |||||||||
| Reference (15) | |||||||||
| Remark | Gene name created from parsing 'genotype' field from CGC strain information | CGC_data_submission | |||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
