WormBase Tree Display for Gene: WBGene00004990
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WBGene00004990 | SMap | S_parent | Sequence | T08A9 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | spp | ||||||
Allele (13) | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation | 00083250 | ||||||
00083251 | |||||||
00083252 | |||||||
00083253 | |||||||
Ortholog (25) | |||||||
Paralog (12) | |||||||
Structured_description | Concise_description | spp-5 encodes a caenopore, a saposin (B) domain-containing protein that is a member of the saposin-like protein (SAPLIP) superfamily containing mammalian NK-lysin and granulysin and the protozoan amoebapore-like proteins; SPP-5 exhibits pore-forming activity and functions as an effector of innate immunity, demonstrating antimicrobial activity against both Gram-positive and Gram-negative bacteria; in addition, SPP-5 is also required for fully normal postembryonic growth and reproduction, likely as a result of its role in killing ingested food, such as E. coli OP50; Northern blot analysisindicates that spp-5 mRNA is expressed constitutively at high levels in the presence of OP50 and a variety of other bacteria; an SPP-5::GFP reporter fusion is expressed exclusively in the intestine; the three-dimensional solution structure of SPP-5 has been determined by NMR spectroscopy revealing five helices, connected by three disulfide bonds, arranged in a folded leaf, the characteristic signature of the SAPLIP family. | Paper_evidence | WBPaper00003435 | |||
WBPaper00035289 | |||||||
WBPaper00035472 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 14 Sep 2010 00:00:00 | ||||||
Automated_description | Enables channel activity. Involved in defense response to Gram-negative bacterium and defense response to Gram-positive bacterium. | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info (5) | |||||||
Experimental_info | RNAi_result | WBRNAi00001969 | Inferred_automatically | RNAi_primary | |||
WBRNAi00082201 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00018423 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00075982 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00082195 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00082196 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00082194 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00082203 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Expr12823 | ||||||
Expr1014643 | |||||||
Expr1032483 | |||||||
Expr1156432 | |||||||
Expr2016083 | |||||||
Expr2034319 | |||||||
Drives_construct | WBCnstr00022886 | ||||||
WBCnstr00023104 | |||||||
WBCnstr00035287 | |||||||
Construct_product | WBCnstr00022886 | ||||||
WBCnstr00035287 | |||||||
Microarray_results (18) | |||||||
Expression_cluster (234) | |||||||
Interaction | WBInteraction000134108 | ||||||
WBInteraction000134112 | |||||||
WBInteraction000134113 | |||||||
WBInteraction000134116 | |||||||
WBInteraction000134193 | |||||||
WBInteraction000450461 | |||||||
WBInteraction000452360 | |||||||
WBInteraction000550093 | |||||||
Map_info | Map | X | Position | -1.77287 | Error | 0.00333 | |
Positive | Positive_clone | T08A9 | Inferred_automatically | From CDS info | |||
From sequence, transcript, pseudogene data | |||||||
Pseudo_map_position | |||||||
Reference | WBPaper00003435 | ||||||
WBPaper00006437 | |||||||
WBPaper00024209 | |||||||
WBPaper00024994 | |||||||
WBPaper00035289 | |||||||
WBPaper00035472 | |||||||
WBPaper00046055 | |||||||
WBPaper00061547 | |||||||
WBPaper00064841 | |||||||
WBPaper00064949 | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |