WormBase Tree Display for Gene: WBGene00004876
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WBGene00004876 | Evidence | CGC_data_submission | |||||
---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | K11G12 | ||||
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | smf | ||||||
Allele (54) | |||||||
Strain | WBStrain00032188 | ||||||
WBStrain00021956 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (27) | |||||||
Contained_in_operon | CEOPX080 | ||||||
Ortholog (33) | |||||||
Paralog | WBGene00004877 | Caenorhabditis elegans | From_analysis | TreeFam | |||
Inparanoid_8 | |||||||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00004878 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
Structured_description | Concise_description | smf-1 encodes one of three C. elegans divalent-metal ion transporters (DMTs) orthologous to the mammalian DMT1 transporters and Saccharomyces cerevisiae Smf proteins; in C. elegans, SMF-1 plays a minor role in manganese uptake, although mutations in smf-1 do display an increased tolerance to manganese exposure; SMF-1 is broadly expressed fromlate embryogenesis through adulthood, with strongest expression seen in the intestine and its associated gland cells; in epithelia, SMF-1 displays partially overlapping localization at the apical plasma membrane with SMF-3; smf-1 transcription is regulated in response to manganese; when expressed in Saccharomyces cerevisiae, smf-1 can rescue the EGTA hypersensitivity of Smf1+2 mutants. | Paper_evidence | WBPaper00035485 | |||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 04 Aug 2010 00:00:00 | ||||||
Automated_description | Predicted to enable cadmium ion transmembrane transporter activity; iron ion transmembrane transporter activity; and manganese ion transmembrane transporter activity. Involved in monoatomic cation homeostasis; negative regulation of cellular response to manganese ion; and response to manganese ion. Located in apical plasma membrane. Expressed in several structures, including excretory cell; hermaphrodite gonad; intestine; nerve ring; and neurons. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); leishmaniasis (multiple); and neurodegenerative disease (multiple). Is an ortholog of human SLC11A1 (solute carrier family 11 member 1) and SLC11A2 (solute carrier family 11 member 2). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model (25) | ||||||
Molecular_info | Corresponding_CDS | K11G12.4a | |||||
Corresponding_CDS_history | K11G12.4:wp129 | ||||||
K11G12.4a:wp184 | |||||||
K11G12.4b:wp248 | |||||||
Corresponding_transcript | K11G12.4b | ||||||
K11G12.4a.1 | |||||||
Other_sequence (32) | |||||||
Associated_feature | WBsf237512 | ||||||
Experimental_info | RNAi_result | WBRNAi00017020 | Inferred_automatically | RNAi_primary | |||
WBRNAi00050614 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00108000 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00082085 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00108005 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00050613 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00082079 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00076571 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00082080 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00082083 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Expr8811 | ||||||
Expr8859 | |||||||
Expr12160 | |||||||
Expr1015427 | |||||||
Expr1032417 | |||||||
Expr1154320 | |||||||
Expr2015904 | |||||||
Expr2034137 | |||||||
Drives_construct | WBCnstr00013568 | ||||||
WBCnstr00019898 | |||||||
WBCnstr00020298 | |||||||
WBCnstr00035346 | |||||||
Construct_product | WBCnstr00013568 | ||||||
WBCnstr00013569 | |||||||
WBCnstr00019900 | |||||||
WBCnstr00035346 | |||||||
Antibody | WBAntibody00001996 | ||||||
Microarray_results (22) | |||||||
Expression_cluster (93) | |||||||
Interaction (35) | |||||||
WBProcess | WBbiopr:00000096 | ||||||
Map_info | Map | X | Position | -2.5294 | Error | 0.00832 | |
Positive | Positive_clone | K11G12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | Multi_point | 4665 | |||||
4666 | |||||||
Pseudo_map_position | |||||||
Reference (18) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |