WormBase Tree Display for Gene: WBGene00004801
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WBGene00004801 | SMap | S_parent | Sequence | F46G10 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | sir-2.2 | Person_evidence | WBPerson1840 | |||||
Sequence_name | F46G10.7 | ||||||||
Molecular_name (11) | |||||||||
Other_name | CELE_F46G10.7 | Accession_evidence | NDB | BX284606 | |||||
Public_name | sir-2.2 | ||||||||
DB_info | Database (12) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:36 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | sir | ||||||||
Allele (77) | |||||||||
Strain | WBStrain00047283 | ||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (19) | |||||||||
Contained_in_operon | CEOPX178 | ||||||||
CEOP2736 | |||||||||
Ortholog (31) | |||||||||
Paralog | WBGene00004802 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
Inparanoid_8 | |||||||||
Panther | |||||||||
WormBase-Compara | |||||||||
WBGene00004800 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
WBGene00004803 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
Structured_description | Concise_description | sir-2.2 encodes one of four C. elegans proteins with similarity to the Saccharomyces cerevisiae Sir2p NAD-dependent histone deacetylase; SIR-2.2 may play a role in genomic stability and protecting the genome against mutations, as loss of SIR-2.2 function via RNA-mediated interference (RNAi) results in an increased level of spontaneous mutagenesis. | Paper_evidence | WBPaper00004566 | |||||
WBPaper00005736 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 11 May 2009 00:00:00 | ||||||||
Automated_description | Predicted to enable NAD+ binding activity and NAD-dependent histone deacetylase activity. Involved in innate immune response. Located in mitochondrion. Is an ortholog of human SIRT4 (sirtuin 4). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Molecular_info | Corresponding_CDS | F46G10.7a | |||||||
F46G10.7b | |||||||||
F46G10.7c | |||||||||
Corresponding_CDS_history | F46G10.7:wp109 | ||||||||
Corresponding_transcript | F46G10.7a.1 | ||||||||
F46G10.7a.2 | |||||||||
F46G10.7b.1 | |||||||||
F46G10.7b.2 | |||||||||
F46G10.7c.1 | |||||||||
Other_sequence (15) | |||||||||
Associated_feature | WBsf648660 | ||||||||
WBsf236559 | |||||||||
Experimental_info | RNAi_result (7) | ||||||||
Expr_pattern (9) | |||||||||
Drives_construct | WBCnstr00003470 | ||||||||
WBCnstr00003833 | |||||||||
WBCnstr00017540 | |||||||||
WBCnstr00035380 | |||||||||
Construct_product | WBCnstr00017540 | ||||||||
WBCnstr00017950 | |||||||||
WBCnstr00035380 | |||||||||
Antibody | WBAntibody00002427 | ||||||||
Microarray_results (27) | |||||||||
Expression_cluster (98) | |||||||||
SAGE_tag | SAGE:taatcttgaa | Strand | Antisense | ||||||
SAGE:atggataaac | Strand | Antisense | |||||||
SAGE:aaacaaattgccattct | Strand | Antisense | |||||||
SAGE:aagttccgtt | Strand | Antisense | |||||||
SAGE:aaacaaattg | Strand | Antisense | |||||||
SAGE:gcgacgatga | Strand | Sense | |||||||
Unambiguously_mapped | |||||||||
SAGE:ccatacttca | Strand | Antisense | |||||||
SAGE:gcgacgatgaagttaga | Strand | Sense | |||||||
Unambiguously_mapped | |||||||||
SAGE:ttaacgttct | Strand | Antisense | |||||||
Interaction (150) | |||||||||
Map_info | Map | X | Position | 11.3226 | Error | 0.035645 | |||
Positive | Positive_clone | F46G10 | Inferred_automatically | From CDS info | |||||
From sequence, transcript, pseudogene data | |||||||||
Pseudo_map_position | |||||||||
Reference (13) | |||||||||
Remark | Sequence connection from [Tissenbaum HA] | ||||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
Method | Gene |