WormBase Tree Display for Gene: WBGene00004140
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WBGene00004140 | SMap | S_parent | Sequence | R09E10 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | ebax | ||||||
Allele (84) | |||||||
Strain | WBStrain00050654 | ||||||
WBStrain00050655 | |||||||
WBStrain00052085 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (20) | |||||||
Ortholog (45) | |||||||
Structured_description | Concise_description | ebax-1 encodes a conserved BC-box-containing protein; EBAX-1 functions as part of a protein quality control mechanism that ensures proper axon guidance; specifically, EBAX-1 functions as a substrate-recognition subunit for misfolded SAX-3 in an Elongin BC-containing Cullin-RING ubiquitin ligase (CRL) complex that promotes degradation of misfolded SAX-3/Robo receptor; EBAX-1 function is particularly critical for thermotolerance of axon guidance; in regulating protein quality control, EBAX-1 functions together and physically interacts with DAF-21, a C. elegans Hsp90 homolog; EBAX-1 is expressed during embryonic and larval stages, and acts cell autonomously in neurons, particularly developing neurons, where it localizes to the cytosol. | Paper_evidence | WBPaper00044158 | |||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 30 Sep 2014 00:00:00 | ||||||
Automated_description | Enables Hsp90 protein binding activity; misfolded protein binding activity; and signaling receptor binding activity. Involved in positive regulation of miRNA catabolic process; regulation of locomotion; and regulation of reproductive process. Located in axon; cytosol; and neuronal cell body. Part of Cul2-RING ubiquitin ligase complex. Expressed in excretory cell; nervous system; and vulval muscle. Is an ortholog of human ZSWIM8 (zinc finger SWIM-type containing 8). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | R09E10.7 | |||||
Corresponding_CDS_history | R09E10.7:wp136 | ||||||
Corresponding_transcript | R09E10.7.1 | ||||||
Other_sequence | Tcir_isotig20209 | ||||||
CRC00576_1 | |||||||
GE625664.1 | |||||||
CR03532 | |||||||
JI163992.1 | |||||||
Dviv_isotig23842 | |||||||
Associated_feature | WBsf660575 | ||||||
WBsf660576 | |||||||
WBsf660577 | |||||||
WBsf228977 | |||||||
WBsf228978 | |||||||
Experimental_info | RNAi_result | WBRNAi00072280 | Inferred_automatically | RNAi_primary | |||
WBRNAi00051626 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00017651 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00034784 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00081120 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00051625 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Expr11256 | ||||||
Expr12595 | |||||||
Expr1028257 | |||||||
Expr1032014 | |||||||
Expr1155298 | |||||||
Expr2011161 | |||||||
Expr2029397 | |||||||
Drives_construct | WBCnstr00019380 | ||||||
WBCnstr00022366 | |||||||
WBCnstr00037933 | |||||||
Construct_product | WBCnstr00019380 | ||||||
WBCnstr00037933 | |||||||
Microarray_results (19) | |||||||
Expression_cluster (134) | |||||||
Interaction | WBInteraction000456278 | ||||||
WBInteraction000523851 | |||||||
WBInteraction000523852 | |||||||
WBInteraction000523853 | |||||||
WBInteraction000549241 | |||||||
WBInteraction000575353 | |||||||
Anatomy_function | WBbtf0601 | ||||||
WBbtf0602 | |||||||
Map_info | Map | IV | Position | 4.57168 | Error | 0.00135 | |
Positive | Positive_clone | R09E10 | Inferred_automatically | From CDS info | |||
From sequence, transcript, pseudogene data | |||||||
Mapping_data | Multi_point (2) | ||||||
Pseudo_map_position | |||||||
Reference (12) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |