WormBase Tree Display for Gene: WBGene00004035
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WBGene00004035 | SMap | S_parent | Sequence | Y73F8A | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | pkd | ||||||
Allele (134) | |||||||
Strain | WBStrain00026468 | ||||||
WBStrain00030885 | |||||||
WBStrain00031062 | |||||||
WBStrain00031013 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (66) | |||||||
Ortholog (57) | |||||||
Paralog | WBGene00003058 | Caenorhabditis elegans | From_analysis | TreeFam | |||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00016889 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
Structured_description (2) | |||||||
Disease_info | Experimental_model | DOID:898 | Homo sapiens | Paper_evidence | WBPaper00003680 | ||
WBPaper00004854 | |||||||
Accession_evidence | OMIM | 613095 | |||||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 30 Apr 2018 00:00:00 | ||||||
Potential_model | DOID:0080322 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9009) | |||
DOID:898 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9009) | ||||
DOID:0110859 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9009) | ||||
DOID:10941 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9009) | ||||
DOID:8466 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9009) | ||||
Disease_relevance | lov-1 and pkd-2 encode the orthologs of human Polycystin-1 and Polycystin-2, which are mutated in autosomal dominant polycystic kidney disease; the polycystins regulate signaling involved in normal renal tubular structure and function; studies in the worm C. elegans have contributed extensively to the finding that cystic kidney diseases can be considered ciliopathies; in elegans lov-1 and pkd-2 are expressed in male ciliary neurons, are required for normal male mating behavior, do not seem to be required for ciliogenesis, and each polycystin may actually have a potential inhibitory function on the other for ciliary function; lov-1 and pkd-1 interact with a single-pass transmembrane protein, CWP-5, though the significance of this interaction for polycystic kidney disease is unknown. | Homo sapiens | Paper_evidence | WBPaper00038373 | |||
Accession_evidence | OMIM | 613095 | |||||
173910 | |||||||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 24 Jan 2012 00:00:00 | ||||||
Models_disease_in_annotation | WBDOannot00000033 | ||||||
Models_disease_asserted | WBDOannot00000514 | ||||||
Molecular_info | Corresponding_CDS | Y73F8A.1 | |||||
Corresponding_CDS_history | Y73F8A.1:wp90 | ||||||
Y73F8A.1:wp143 | |||||||
Corresponding_transcript | Y73F8A.1.1 | ||||||
Other_sequence | CRC10242_1 | ||||||
CR05211 | |||||||
FK801188.1 | |||||||
JI174536.1 | |||||||
Associated_feature | WBsf998698 | ||||||
WBsf998699 | |||||||
WBsf1018743 | |||||||
WBsf1018744 | |||||||
WBsf1018745 | |||||||
WBsf1018746 | |||||||
WBsf231243 | |||||||
Experimental_info | RNAi_result | WBRNAi00066584 | Inferred_automatically | RNAi_primary | |||
WBRNAi00000585 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00021407 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00021408 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00058373 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00112685 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00037811 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern (17) | |||||||
Drives_construct (54) | |||||||
Construct_product (11) | |||||||
Antibody | WBAntibody00000407 | ||||||
WBAntibody00002558 | |||||||
WBAntibody00002633 | |||||||
Microarray_results (22) | |||||||
Expression_cluster (66) | |||||||
Interaction (66) | |||||||
WBProcess | WBbiopr:00000012 | ||||||
Map_info | Map | IV | Position | 13.0445 | |||
Positive | Positive_clone | Y73F8A | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | Multi_point | 4982 | |||||
Pseudo_map_position | |||||||
Reference (156) | |||||||
Remark | The use of the name pdk-2 for this gene was due to a typo in the original paper [krb 020128] | ||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||
[140923 pad] Modified Map position as it was a reverse physical that could not be fixed by automated methods. | |||||||
Method | Gene |