WormBase Tree Display for Gene: WBGene00004008
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WBGene00004008 | SMap | S_parent | Sequence | F22E10 | ||
---|---|---|---|---|---|---|
Identity (6) | ||||||
Gene_info | Biotype | SO:0001217 | ||||
Gene_class | pgp | |||||
Allele (62) | ||||||
Strain | WBStrain00001996 | |||||
WBStrain00032692 | ||||||
RNASeq_FPKM (74) | ||||||
GO_annotation (13) | ||||||
Contained_in_operon | CEOPX110 | |||||
Ortholog (53) | ||||||
Paralog (24) | ||||||
Structured_description | Concise_description | pgp-14 encodes a member of the ABC transporter family with high similarity to the vertebrate MDR (multidrug resistance) family; PGP-14 is predicted to function as a transmembrane protein that couples energy to transport of various molecules across membranes, but as loss of pgp-14 activity via large-scale RNAi screens does not result in any obvious defects, the precise role of pgp-14 in C. elegans development and/or behavior is not yet known; pgp-14 promoter-gfp fusion proteins are expressed in larvae and adults in the anterior pharynx. | Paper_evidence | WBPaper00006421 | ||
WBPaper00006525 | ||||||
WBPaper00024561 | ||||||
Curator_confirmed (2) | ||||||
Date_last_updated | 07 Mar 2006 00:00:00 | |||||
Automated_description | Predicted to enable ATPase-coupled transmembrane transporter activity. Involved in response to nematicide. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); and hematologic cancer (multiple). Is an ortholog of human ABCB1 (ATP binding cassette subfamily B member 1); ABCB4 (ATP binding cassette subfamily B member 4); and ABCB5 (ATP binding cassette subfamily B member 5). | Paper_evidence | WBPaper00065943 | |||
Curator_confirmed (2) | ||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | |||||
Date_last_updated | 29 Nov 2023 00:00:00 | |||||
Disease_info | Potential_model (39) | |||||
Molecular_info | Corresponding_CDS | F22E10.3 | ||||
Corresponding_transcript | F22E10.3.1 | |||||
Other_sequence | JI168113.1 | |||||
JI235600.1 | ||||||
JI231282.1 | ||||||
JI164894.1 | ||||||
Acan_isotig21429 | ||||||
JI218053.1 | ||||||
CJC02657_1 | ||||||
ASC19568_1 | ||||||
JI241304.1 | ||||||
Associated_feature | WBsf238081 | |||||
WBsf238082 | ||||||
WBsf238083 | ||||||
Experimental_info | RNAi_result | WBRNAi00045324 | Inferred_automatically | RNAi_primary | ||
WBRNAi00000347 | Inferred_automatically | RNAi_primary | ||||
WBRNAi00077361 | Inferred_automatically | RNAi_primary | ||||
WBRNAi00013753 | Inferred_automatically | RNAi_primary | ||||
Expr_pattern | Expr3326 | |||||
Expr3327 | ||||||
Expr4618 | ||||||
Expr5828 | ||||||
Expr1031917 | ||||||
Expr1149248 | ||||||
Expr2014867 | ||||||
Expr2033102 | ||||||
Drives_construct | WBCnstr00002780 | |||||
WBCnstr00011322 | ||||||
WBCnstr00011323 | ||||||
WBCnstr00012122 | ||||||
WBCnstr00035743 | ||||||
Construct_product | WBCnstr00035743 | |||||
Microarray_results (16) | ||||||
Expression_cluster (235) | ||||||
Interaction (33) | ||||||
Map_info (3) | ||||||
Reference (12) | ||||||
Remark | Sequence connection from [Sheps JA, Baillie DL] [040902 ck1] | |||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |