WormBase Tree Display for Gene: WBGene00003931
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WBGene00003931 | Evidence | CGC_data_submission | |||||||
---|---|---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | CHROMOSOME_III | ||||||
Identity | Version | 1 | |||||||
Name | CGC_name | pat-4 | Person_evidence | WBPerson1562 | |||||
Sequence_name | C29F9.7 | ||||||||
Molecular_name | C29F9.7 | ||||||||
C29F9.7.1 | |||||||||
CE19706 | |||||||||
Other_name | CELE_C29F9.7 | Accession_evidence | NDB | BX284603 | |||||
Public_name | pat-4 | ||||||||
DB_info | Database | AceView | gene | 3A708 | |||||
WormQTL | gene | WBGene00003931 | |||||||
WormFlux | gene | WBGene00003931 | |||||||
NDB | locus_tag | CELE_C29F9.7 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00003931|UniProtKB=Q9TZC4 | |||||||
family | PTHR44329 | ||||||||
NCBI | gene | 175175 | |||||||
RefSeq | protein | NM_064738.8 | |||||||
SwissProt | UniProtAcc | Q9TZC4 | |||||||
TREEFAM | TREEFAM_ID | TF315194 | |||||||
UniProt_GCRP | UniProtAcc | Q9TZC4 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | pat | ||||||||
Allele (312) | |||||||||
Legacy_information | [Williams DB] Severe Pat phenotype, all alleles similar | ||||||||
[C.elegansII] st552 : severe Pat phenotype. OA3: st551, st579, st580 (all similar). [Williams and Waterston 1994; RW] | |||||||||
[MacKinnon C] Predicted gene C29F9.7, encoding homologue of vertebrate integrin-linked kinase | |||||||||
Strain | WBStrain00002637 | ||||||||
WBStrain00033521 | |||||||||
WBStrain00040330 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (46) | |||||||||
Ortholog (34) | |||||||||
Paralog (11) | |||||||||
Structured_description | Concise_description | The pat-4 gene encodes a serine/threonine kinase orthologous to human integrin-linked kinase (ILK, OMIM:602366) and is required for formation of integrin-mediated muscle cell attachments during embryogenesis; PAT-4 probably functions as an adaptor molecule and localizes to dense bodies and M lines; PAT-4 forms a ternary complex with PAT-6/actopaxin and UNC-112, and requires UNC-112, UNC-52/perlecan, PAT-2/alpha integrin, and PAT-3/beta integrin for proper localization to newly forming integrin adhesion complexes. | Paper_evidence | WBPaper00005261 | |||||
WBPaper00005915 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
Automated_description | Enables integrin binding activity and protein-macromolecule adaptor activity. Involved in several processes, including integrin-mediated signaling pathway; organelle organization; and positive regulation of supramolecular fiber organization. Located in adherens junction; basal plasma membrane; and contractile fiber. Part of integrin complex. Expressed in body wall musculature; gonad; non-striated muscle; pharynx; and touch receptor neurons. Human ortholog(s) of this gene implicated in ovarian cancer; pancreatic cancer; and prostate adenocarcinoma. Is an ortholog of human ILK (integrin linked kinase). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:10283 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6040) | ||||
DOID:1793 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6040) | ||||||
DOID:2526 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6040) | ||||||
DOID:2394 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6040) | ||||||
Molecular_info | Corresponding_CDS | C29F9.7 | |||||||
Corresponding_transcript | C29F9.7.1 | ||||||||
Other_sequence (89) | |||||||||
Associated_feature (3) | |||||||||
Experimental_info | RNAi_result (40) | ||||||||
Expr_pattern | Chronogram438 | ||||||||
Expr1888 | |||||||||
Expr5379 | |||||||||
Expr11437 | |||||||||
Expr14519 | |||||||||
Expr1010218 | |||||||||
Expr1031864 | |||||||||
Expr1145524 | |||||||||
Expr2014752 | |||||||||
Expr2032986 | |||||||||
Drives_construct | WBCnstr00003184 | ||||||||
WBCnstr00010504 | |||||||||
WBCnstr00021447 | |||||||||
WBCnstr00041071 | |||||||||
Construct_product | WBCnstr00010504 | ||||||||
WBCnstr00019202 | |||||||||
WBCnstr00021626 | |||||||||
WBCnstr00021697 | |||||||||
WBCnstr00041071 | |||||||||
Antibody (2) | |||||||||
Microarray_results (19) | |||||||||
Expression_cluster (141) | |||||||||
Interaction (83) | |||||||||
WBProcess | WBbiopr:00000006 | ||||||||
Map_info | Map | III | Position | -26.9858 | Error | 0.037333 | |||
Well_ordered | |||||||||
Positive | Positive_clone | C29F9 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | Multi_point | 3016 | |||||||
3017 | |||||||||
Reference (49) | |||||||||
Remark | Data extracted from Williams & Waterston 1994 | ||||||||
Sequence connection from [Rogalski TM, Williams BD] | |||||||||
Method | Gene |