WormBase Tree Display for Gene: WBGene00003920
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WBGene00003920 | SMap | S_parent | Sequence | M117 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | par | ||||||
Allele (23) | |||||||
Legacy_information | [C.elegansII] it55 : maternal effect lethal; 2nd cleavage spindles transverse, asters spherical (resembles Par-2); most embryos lack gut granules. OA1. [Morton et al. 1992; KK] | ||||||
[C.elegansII] NMK. Encodes predicted protein 78% identicalto Drosophila and bovine 14-3-3 proteins. [Wang and Shakes 1994; DS] | |||||||
Strain | WBStrain00023556 | ||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (31) | |||||||
Ortholog (48) | |||||||
Paralog | WBGene00001502 | Caenorhabditis elegans | From_analysis | Inparanoid_8 | |||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00010919 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
Structured_description | Concise_description | PAR-5 encodes one of two C. elegans 14-3-3 proteins; par-5 is essential for early embryonic development, particularly for early embryonic asymmetry; PAR-5 also functions in a Wnt/MAPK signaling pathway to regulate the nuclear level of the POP-1/TCF transcription factor; PAR-5 has been shown to physically interact with a number of proteins, including those involved in G protein signaling pathways and regulation of adult lifespan. | Paper_evidence | WBPaper00005079 | |||
WBPaper00006460 | |||||||
WBPaper00027195 | |||||||
WBPaper00027682 | |||||||
WBPaper00027763 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson567 | |||||||
Date_last_updated | 22 Mar 2011 00:00:00 | ||||||
Automated_description | Involved in several processes, including cellular localization; determination of adult lifespan; and first cell cycle pseudocleavage. Located in cell cortex and nucleus. Expressed in head neurons. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); ovarian cancer; and urinary bladder cancer. Is an ortholog of human YWHAB (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta) and YWHAZ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:8719 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10773) | ||
DOID:11054 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10773) | ||||
DOID:2871 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10773) | ||||
DOID:2671 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10773) | ||||
DOID:684 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12855) | ||||
DOID:2101 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10773) | ||||
DOID:2394 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10773) | ||||
Molecular_info | Corresponding_CDS | M117.2a | |||||
M117.2b | |||||||
Corresponding_transcript | M117.2a.1 | ||||||
M117.2a.2 | |||||||
M117.2a.3 | |||||||
M117.2a.4 | |||||||
M117.2b.1 | |||||||
Other_sequence (92) | |||||||
Associated_feature (12) | |||||||
Experimental_info | RNAi_result (81) | ||||||
Expr_pattern (13) | |||||||
Drives_construct (11) | |||||||
Construct_product (13) | |||||||
Antibody | WBAntibody00000448 | ||||||
Microarray_results (27) | |||||||
Expression_cluster (193) | |||||||
Interaction (448) | |||||||
WBProcess | WBbiopr:00000017 | ||||||
WBbiopr:00000120 | |||||||
Map_info | Map | IV | Position | 5.3063 | Error | 0.001806 | |
Well_ordered | |||||||
Positive | Positive_clone | C38H7 | |||||
M117 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | 2_point | 3263 | |||||
3810 | |||||||
Multi_point | 1262 | ||||||
Pos_neg_data | 3264 | ||||||
3265 | |||||||
3266 | |||||||
6749 | |||||||
8178 | |||||||
Reference (105) | |||||||
Picture | WBPicture0000013084 | ||||||
Remark | The ftt-1 gene was merged into par-5 following advice from J .Hodgkin (evidence from [Morton DG, Shakes DC, Kemphues K]). krb 02/03/04 | ||||||
Sequence connection from [Morton DG, Shakes DC, Kemphues K], 02/06/13 krb. | |||||||
Method | Gene |