WormBase Tree Display for Gene: WBGene00002982
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WBGene00002982 | Evidence | CGC_data_submission | |||||
---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | B0336 | ||||
Identity | Version | 2 | |||||
Name | CGC_name | lgg-3 | Person_evidence | WBPerson321 | |||
Sequence_name | B0336.8 | ||||||
Molecular_name | B0336.8 | ||||||
B0336.8.1 | |||||||
CE00776 | |||||||
Other_name | atg-12 | Paper_evidence | WBPaper00028973 | ||||
Person_evidence | WBPerson649 | ||||||
CELE_B0336.8 | Accession_evidence | NDB | BX284603 | ||||
Public_name | lgg-3 | ||||||
DB_info | Database (10) | ||||||
Species | Caenorhabditis elegans | ||||||
History | Version_change (2) | ||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | lgg | ||||||
Allele | WBVar00250621 | ||||||
WBVar01500260 | |||||||
WBVar01500122 | |||||||
WBVar01500123 | |||||||
WBVar00829183 | |||||||
WBVar00829184 | |||||||
WBVar00829185 | |||||||
WBVar00275641 | |||||||
WBVar02053280 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (16) | |||||||
Contained_in_operon | CEOP3324 | ||||||
Ortholog (34) | |||||||
Structured_description | Concise_description | lgg-3 encodes a hydrophilic protein that is orthologous to Saccharomyces cerevisiae autophagy protein Apg12p; by homology, LGG-3 is predicted to function as a modifier protein required for a protein conjugation system essential for autophagy; in the context of this conjugation system, LGG-3 is predicted to interact with Apg7p and Apg5p homologs (encoded by M7.5 and Y71G12B.12a, respectively) to effect bulk degradation of cytoplasmic components under conditions of starvation or cellular remodeling; free LGG-3 is predicted to localize to the cytoplasm, while LGG-3 conjugated to the Apg5p homolog is predicted to associate with membrane compartments; loss of lgg-3 activity via large-scale RNAi screens results in no obvious developmental or behavioral abnormalities. | Paper_evidence | WBPaper00004403 | |||
WBPaper00005654 | |||||||
WBPaper00013631 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||
Automated_description | Involved in cellular response to toxic substance; determination of adult lifespan; and xenophagy. Acts upstream of or within with a positive effect on plasma membrane repair. Located in autophagosome membrane. Is an ortholog of human ATG12 (autophagy related 12). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | B0336.8 | |||||
Corresponding_transcript | B0336.8.1 | ||||||
Associated_feature | WBsf651070 | ||||||
WBsf655435 | |||||||
Experimental_info | RNAi_result (34) | ||||||
Expr_pattern | Expr1014494 | ||||||
Expr1031382 | |||||||
Expr1143130 | |||||||
Expr2013144 | |||||||
Expr2031376 | |||||||
Drives_construct | WBCnstr00036307 | ||||||
Construct_product | WBCnstr00036307 | ||||||
Antibody | WBAntibody00002571 | ||||||
Microarray_results (16) | |||||||
Expression_cluster (105) | |||||||
Interaction (26) | |||||||
Map_info | Map | III | Position | -1.45276 | Error | 0.000601 | |
Positive | Positive_clone | B0336 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Pseudo_map_position | |||||||
Reference (17) | |||||||
Remark | Sequence connection from [Kimura Y] | ||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||
Method | Gene |