WormBase Tree Display for Gene: WBGene00002978
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WBGene00002978 | SMap | S_parent | Sequence | Y105E8B | ||
---|---|---|---|---|---|---|
Identity (6) | ||||||
Gene_info | Biotype | SO:0001217 | ||||
Gene_class | lev | |||||
Reference_allele | WBVar00275207 | |||||
Allele (206) | ||||||
Legacy_information | x12 : slightly long uncoordinated mild twitcher phenotype grows well in 1 mM levamisole; strong semi-dominant suppressor of unc-90(e1463). ES3 ME2. NA3 (x1 : twitcher e1724 : lethal). | |||||
See also e1724 | ||||||
[Williams BD] Pat (paralysed arrest at two-fold), severe paralysis; st577 and st566 have some pharyngeal pumping. | ||||||
[C.elegansII] x12 : slightly long, uncoordinated, mild twitcher phenotype; grows well in 1 mM levamisole; strong semi-dominant suppressor of unc-90(e1463). ES3 ME2. OA6: x1 (twitcher), e1724 (lethal). Also Pat (paralysed arrest at two-fold) alleles: st536 (severe paralysis),st577, st566 (some pharyngeal pumping. Greatly reduced staining for tropomyosin, probably corresponds to structural gene tmy-1. [Lewis et al. 1980; Williams and Waterston 1994; HK; ZZ]lfeLet-23 FErtility effector/regulator.PS. | ||||||
[C.elegansII] Probably corresponds to lev-11. Three transcripts encoding tropomyosin, probable body wall and non-muscle isoforms (284 aa,different C-termini) and pharyngeal isoform (256 aa, different promoter). [Kagawa et al. 1995; HK] | ||||||
Strain | WBStrain00002959 | |||||
WBStrain00033515 | ||||||
WBStrain00033518 | ||||||
WBStrain00033524 | ||||||
WBStrain00040917 | ||||||
WBStrain00040918 | ||||||
WBStrain00004923 | ||||||
RNASeq_FPKM (74) | ||||||
GO_annotation (20) | ||||||
Ortholog (47) | ||||||
Structured_description | Concise_description | lev-11 encodes tropomyosin, an actin-binding contractile structural protein orthologous to human TROPOMYOSIN 1 (TPM1; OMIM:191010), which when mutated leads to familial hypertrophic cardiomyopathy; LEV-11 is required for embryonic development, normal body morphology, and locomotion; expressed as multiple tissue-specific isoforms generated by alternative mRNA splicing and promoter use, LEV-11 is detected in several tissues including muscle, pharynx, intestine, and the germ line. | Paper_evidence | WBPaper00002748 | ||
WBPaper00004944 | ||||||
Curator_confirmed (3) | ||||||
Date_last_updated | 17 Jun 2004 00:00:00 | |||||
Automated_description | Enables actin filament binding activity. Involved in several processes, including actin filament organization; regulation of actin polymerization or depolymerization; and spicule insertion. Located in striated muscle thin filament. Expressed in several structures, including body wall musculature; germ line; intestine; non-striated muscle; and pharynx. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple); muscle tissue disease (multiple); and thyroid gland papillary carcinoma. Is an ortholog of several human genes including TPM1 (tropomyosin 1); TPM2 (tropomyosin 2); and TPM3 (tropomyosin 3). | Paper_evidence | WBPaper00065943 | |||
Curator_confirmed (2) | ||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | |||||
Date_last_updated | 29 Nov 2023 00:00:00 | |||||
Disease_info | Potential_model | DOID:0111597 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12011) | |
DOID:0110926 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12012) | |||
DOID:0110309 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12010) | |||
DOID:0110457 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12010) | |||
DOID:3969 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12012) | |||
DOID:0110932 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12011) | |||
DOID:0080326 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12010) | |||
DOID:0080102 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12012) | |||
DOID:2218 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12013) | |||
Molecular_info | Corresponding_CDS (19) | |||||
Corresponding_CDS_history | Y105E8B.1b:wp62 | |||||
Y105E8B.1b:wp114 | ||||||
Y105E8B.1c:wp62 | ||||||
Corresponding_transcript (20) | ||||||
Other_sequence (913) | ||||||
Associated_feature (35) | ||||||
Experimental_info | RNAi_result (31) | |||||
Expr_pattern (15) | ||||||
Drives_construct (12) | ||||||
Construct_product | WBCnstr00010369 | |||||
WBCnstr00012505 | ||||||
WBCnstr00016244 | ||||||
WBCnstr00041176 | ||||||
Antibody | WBAntibody00000099 | |||||
WBAntibody00000422 | ||||||
WBAntibody00000423 | ||||||
WBAntibody00000472 | ||||||
Microarray_results (61) | ||||||
Expression_cluster (304) | ||||||
Interaction (175) | ||||||
WBProcess | WBbiopr:00000006 | |||||
Map_info (4) | ||||||
Reference (90) | ||||||
Remark | Data extracted from Williams & Waterston 1994 | |||||
The gene tmy-1 was merged into this gene by krb on advice of JAH 25/02/02 | ||||||
Method | Gene |