WormBase Tree Display for Gene: WBGene00002978
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WBGene00002978 | SMap | S_parent | Sequence | Y105E8B | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | lev-11 | Person_evidence | WBPerson368 | |||||
Sequence_name | Y105E8B.1 | ||||||||
Molecular_name (58) | |||||||||
Other_name | tmy-1 | ||||||||
Y105E8B.c | Curator_confirmed | WBPerson1983 | |||||||
Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
CeTM | Paper_evidence | WBPaper00005168 | |||||||
WBPaper00032338 | |||||||||
CELE_Y105E8B.1 | Accession_evidence | NDB | BX284601 | ||||||
Public_name | lev-11 | ||||||||
DB_info | Database (12) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | lev | ||||||||
Reference_allele | WBVar00275207 | ||||||||
Allele (206) | |||||||||
Legacy_information (5) | |||||||||
Strain | WBStrain00002959 | ||||||||
WBStrain00033515 | |||||||||
WBStrain00033518 | |||||||||
WBStrain00033524 | |||||||||
WBStrain00040917 | |||||||||
WBStrain00040918 | |||||||||
WBStrain00004923 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (20) | |||||||||
Ortholog (47) | |||||||||
Structured_description | Concise_description | lev-11 encodes tropomyosin, an actin-binding contractile structural protein orthologous to human TROPOMYOSIN 1 (TPM1; OMIM:191010), which when mutated leads to familial hypertrophic cardiomyopathy; LEV-11 is required for embryonic development, normal body morphology, and locomotion; expressed as multiple tissue-specific isoforms generated by alternative mRNA splicing and promoter use, LEV-11 is detected in several tissues including muscle, pharynx, intestine, and the germ line. | Paper_evidence | WBPaper00002748 | |||||
WBPaper00004944 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
WBPerson1823 | |||||||||
WBPerson567 | |||||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
Automated_description | Enables actin filament binding activity. Involved in several processes, including actin filament organization; regulation of actin polymerization or depolymerization; and spicule insertion. Located in striated muscle thin filament. Expressed in several structures, including body wall musculature; germ line; intestine; non-striated muscle; and pharynx. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple); muscle tissue disease (multiple); and thyroid gland papillary carcinoma. Is an ortholog of several human genes including TPM1 (tropomyosin 1); TPM2 (tropomyosin 2); and TPM3 (tropomyosin 3). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:0111597 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12011) | ||||
DOID:0110926 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12012) | ||||||
DOID:0110309 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12010) | ||||||
DOID:0110457 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12010) | ||||||
DOID:3969 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12012) | ||||||
DOID:0110932 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12011) | ||||||
DOID:0080326 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12010) | ||||||
DOID:0080102 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12012) | ||||||
DOID:2218 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12013) | ||||||
Molecular_info | Corresponding_CDS (19) | ||||||||
Corresponding_CDS_history | Y105E8B.1b:wp62 | ||||||||
Y105E8B.1b:wp114 | |||||||||
Y105E8B.1c:wp62 | |||||||||
Corresponding_transcript (20) | |||||||||
Other_sequence (913) | |||||||||
Associated_feature (35) | |||||||||
Experimental_info (9) | |||||||||
Map_info | Map | I | Position | 25.8125 | Error | 0.018971 | |||
Well_ordered | |||||||||
Positive | Positive_clone | Y105E8B | Inferred_automatically | From CDS info | |||||
From sequence, transcript, pseudogene data | |||||||||
Mapping_data | 2_point (6) | ||||||||
Multi_point (11) | |||||||||
Pos_neg_data (13) | |||||||||
Reference (90) | |||||||||
Remark | Data extracted from Williams & Waterston 1994 | ||||||||
The gene tmy-1 was merged into this gene by krb on advice of JAH 25/02/02 | |||||||||
Method | Gene |