WormBase Tree Display for Gene: WBGene00002601
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| WBGene00002601 | SMap | S_parent | Sequence | F26B1 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | let-381 | Person_evidence | WBPerson533 | |||||
| Sequence_name | F26B1.7 | ||||||||
| Molecular_name | F26B1.7 | ||||||||
| F26B1.7.1 | |||||||||
| CE28006 | |||||||||
| Other_name | CELE_F26B1.7 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | let-381 | ||||||||
| DB_info | Database | AceView | gene | 1G898 | |||||
| WormQTL | gene | WBGene00002601 | |||||||
| WormFlux | gene | WBGene00002601 | |||||||
| NDB | locus_tag | CELE_F26B1.7 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00002601|UniProtKB=P91278 | |||||||
| family | PTHR11829 | ||||||||
| NCBI | gene | 172331 | |||||||
| RefSeq | protein | NM_059425.4 | |||||||
| SwissProt | UniProtAcc | P91278 | |||||||
| UniProt_GCRP | UniProtAcc | P91278 | |||||||
| OMIM | gene | 601089 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:28 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | let | ||||||||
| Allele (40) | |||||||||
| Legacy_information | [McDowall JS] Early larval lethal | ||||||||
| [C.elegansII] h107 : embryonic or early larval lethal. OA2: h495, h747. Cloned (cosmid F26B1). [Howell et al. 1987; KR] | |||||||||
| Strain | WBStrain00023690 | ||||||||
| WBStrain00035996 | |||||||||
| WBStrain00052018 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (16) | |||||||||
| Ortholog (42) | |||||||||
| Paralog | WBGene00001434 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00001438 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00001440 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00001441 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00001442 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00003017 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00003976 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00004013 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00006853 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00000912 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | let-381 encodes a forkhead transcription factor and was identified in a screen for essential genes; let-381 is essential for development at different times as mutants exhibit embryonic and early larval lethality, with a few developing to sterile adults; inactivation of let-381 using RNA interference results in adults with mesodermal cell lineage defects and a reduced number of coelomocytes; reporter-gene assays indicate LET-381 is expressed when the embryo starts to elongate and continues to be expressed through all larval stages and into the adult. | Paper_evidence | WBPaper00002829 | |||||
| WBPaper00002830 | |||||||||
| WBPaper00005730 | |||||||||
| WBPaper00018404 | |||||||||
| WBPaper00019541 | |||||||||
| Person_evidence | WBPerson381 | ||||||||
| Curator_confirmed | WBPerson13481 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables sequence-specific DNA binding activity. Involved in mesodermal cell fate specification; nematode larval development; and positive regulation of mesodermal cell fate specification. Located in nucleus. Expressed in M.dlp; M.drp; body wall muscle cell from M lineage; and coelomocyte. Human ortholog(s) of this gene implicated in persistent fetal circulation syndrome. Is an ortholog of human FOXF1 (forkhead box F1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:13042 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3809) | ||||
| Molecular_info | Corresponding_CDS | F26B1.7 | |||||||
| Corresponding_transcript | F26B1.7.1 | ||||||||
| Other_sequence | CJC05462_1 | ||||||||
| Dviv_isotig25947 | |||||||||
| TSC04884_1 | |||||||||
| Acan_isotig02194 | |||||||||
| JI173213.1 | |||||||||
| Oden_isotig23420 | |||||||||
| TS05801 | |||||||||
| Associated_feature | WBsf649232 | ||||||||
| WBsf978794 | |||||||||
| WBsf983893 | |||||||||
| WBsf983894 | |||||||||
| WBsf983895 | |||||||||
| WBsf1009935 | |||||||||
| WBsf1009936 | |||||||||
| WBsf219572 | |||||||||
| Transcription_factor | WBTranscriptionFactor000179 | ||||||||
| Experimental_info | RNAi_result (15) | ||||||||
| Expr_pattern | Expr2343 | ||||||||
| Expr2344 | |||||||||
| Expr9018 | |||||||||
| Expr1027729 | |||||||||
| Expr1031357 | |||||||||
| Expr1149512 | |||||||||
| Expr2013055 | |||||||||
| Expr2031287 | |||||||||
| Drives_construct | WBCnstr00006115 | ||||||||
| WBCnstr00010780 | |||||||||
| WBCnstr00010781 | |||||||||
| WBCnstr00013675 | |||||||||
| WBCnstr00036326 | |||||||||
| Construct_product | WBCnstr00006029 | ||||||||
| WBCnstr00006030 | |||||||||
| WBCnstr00006113 | |||||||||
| WBCnstr00006114 | |||||||||
| WBCnstr00006115 | |||||||||
| WBCnstr00013675 | |||||||||
| WBCnstr00036326 | |||||||||
| Antibody | WBAntibody00002137 | ||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (107) | |||||||||
| Interaction (34) | |||||||||
| Map_info | Map | I | Position | 1.01515 | Error | 0.012812 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | C38F7 | |||||||
| F26B1 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Negative | Negative_clone | C03F7 | |||||||
| C29F10 | |||||||||
| C32G12 | |||||||||
| C40A4 | |||||||||
| C48E7 | |||||||||
| K04F10 | |||||||||
| ZC338 | |||||||||
| Mapping_data | 2_point | 2545 | |||||||
| Multi_point | 1031 | ||||||||
| 4438 | |||||||||
| Pos_neg_data (13) | |||||||||
| Reference (23) | |||||||||
| Remark | [McDowall JS] Extrachromosomal array containing three cosmids generated, then manipulated genetically. Rescuing cosmids deduced from experiments with other arrays. Rescuing array contained both positive clones. | ||||||||
| Method | Gene |
