WormBase Tree Display for Gene: WBGene00001953
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WBGene00001953 | SMap | S_parent | Sequence | C02B8 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | hlh | ||||||
Allele (88) | |||||||
Strain | WBStrain00027639 | ||||||
WBStrain00027640 | |||||||
WBStrain00030584 | |||||||
WBStrain00030587 | |||||||
WBStrain00030588 | |||||||
WBStrain00033322 | |||||||
WBStrain00037705 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (19) | |||||||
Ortholog (37) | |||||||
Paralog | WBGene00000561 | Caenorhabditis elegans | From_analysis | TreeFam | |||
WBGene00001954 | Caenorhabditis elegans | From_analysis | Panther | ||||
WBGene00001957 | Caenorhabditis elegans | From_analysis | TreeFam | ||||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00003595 | Caenorhabditis elegans | From_analysis | TreeFam | ||||
WBGene00001962 | Caenorhabditis elegans | From_analysis | Panther | ||||
WBGene00001981 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00001956 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
Structured_description | Concise_description | The hlh-8 gene encodes a helix-loop-helix protein required for normal muscle development, and hence for normal defecation and egg-laying. | Paper_evidence | WBPaper00003174 | |||
WBPaper00004154 | |||||||
WBPaper00004482 | |||||||
WBPaper00005080 | |||||||
Curator_confirmed | WBPerson567 | ||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||
Automated_description | Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in mesodermal cell fate specification; positive regulation of transcription by RNA polymerase II; and vulval cell fate specification. Predicted to be located in nucleus. Expressed in several structures, including M.dla; M.dra; M.vla; body wall muscle cell from M lineage; and enteric muscle. Used to study Saethre-Chotzen syndrome. Human ortholog(s) of this gene implicated in several diseases, including Barber-Say syndrome; Sweeney-Cox syndrome; and synostosis (multiple). Is an ortholog of human TWIST2 (twist family bHLH transcription factor 2). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info (3) | |||||||
Models_disease_in_annotation | WBDOannot00001006 | ||||||
Models_disease_asserted | WBDOannot00000126 | ||||||
WBDOannot00001005 | |||||||
Molecular_info | Corresponding_CDS | C02B8.4 | |||||
Corresponding_transcript | C02B8.4.1 | ||||||
C02B8.4.2 | |||||||
Other_sequence | Oden_isotig22148 | ||||||
ES413014.1 | |||||||
JI213846.1 | |||||||
Associated_feature (14) | |||||||
Gene_product_binds (7249) | |||||||
Transcription_factor | WBTranscriptionFactor000066 | ||||||
WBTranscriptionFactor000083 | |||||||
Experimental_info | RNAi_result (14) | ||||||
Expr_pattern (13) | |||||||
Drives_construct (19) | |||||||
Construct_product (11) | |||||||
Antibody | WBAntibody00000188 | ||||||
WBAntibody00001852 | |||||||
Microarray_results (19) | |||||||
Expression_cluster (88) | |||||||
Interaction (121) | |||||||
WBProcess | WBbiopr:00000040 | ||||||
Map_info | Map | X | Position | -0.530654 | Error | 0.011006 | |
Positive | Positive_clone | C02B8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | Multi_point | 4404 | |||||
4750 | |||||||
4876 | |||||||
5663 | |||||||
Pseudo_map_position | |||||||
Reference (71) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |