WormBase Tree Display for Gene: WBGene00001886

WBGene00001886 SMap: S_parent: Sequence: ZK131
  Identity: Version: 1
    Name: CGC_name: his-12 Person_evidence: WBPerson160
      Sequence_name: ZK131.6
      Molecular_name: ZK131.6
        ZK131.6.1
        CE04501
      Other_name: CELE_ZK131.6 Accession_evidence: NDB BX284602
      Public_name: his-12
    DB_info: Database: AceView gene 2O112
        WormFlux gene WBGene00001886
        NDB locus_tag CELE_ZK131.6
        NCBI gene 175028
        RefSeq protein NM_064490.1
        SwissProt UniProtAcc P09588
        UniProt_GCRP UniProtAcc P09588
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:26 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: his
    Allele: WBVar01499702
      WBVar01498435
      WBVar01498941
    Legacy_information: [C.elegansII] NMK. Histone type H2A. HIS3 cluster. [Roberts et al. 1989; EM]
    In_cluster: HIS3_cluster
    RNASeq_FPKM (74)
    GO_annotation: 00109571
      00109572
      00109573
      00109574
    Ortholog (200)
    Paralog (18)
    Structured_description: Concise_description: his-12 encodes an H2A histone; his-12 is contained within the histone gene cluster HIS3. Paper_evidence: WBPaper00001150
          Curator_confirmed: WBPerson48
            WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be a structural constituent of chromatin. Predicted to be part of nucleosome. Human ortholog(s) of this gene implicated in oral mucosa leukoplakia and oral squamous cell carcinoma. Is an ortholog of human H2AX (H2A.X variant histone). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0050866 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4739)
      DOID:9655 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4739)
  Molecular_info: Corresponding_CDS: ZK131.6
    Corresponding_transcript: ZK131.6.1
    Other_sequence (11)
    Associated_feature: WBsf224210
  Experimental_info: RNAi_result: WBRNAi00110824 Inferred_automatically: RNAi_primary
      WBRNAi00025036 Inferred_automatically: RNAi_primary
      WBRNAi00065092 Inferred_automatically: RNAi_primary
      WBRNAi00082055 Inferred_automatically: RNAi_primary
      WBRNAi00082060 Inferred_automatically: RNAi_primary
      WBRNAi00027053 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1162654
    Drives_construct: WBCnstr00036625
    Construct_product: WBCnstr00036625
    Microarray_results: SMD_ZK131.6
      172835_x_at
      Aff_ZK131.6
      GPL8304_CE_WBGene00001917_B
    Expression_cluster (106)
    Interaction (229)
  Map_info: Map: II Position: 20.3002 Error: 0.084477
    Positive: Positive_clone: F35H10
        ZK131 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4469
    Pseudo_map_position
  Reference: WBPaper00001150
    WBPaper00002006
    WBPaper00005142
    WBPaper00005182
    WBPaper00015440
    WBPaper00038491
    WBPaper00055090
  Remark: cannot be sequence C50F4.13 on V. removing [sdm 000920]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene