WormBase Tree Display for Gene: WBGene00001837
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| WBGene00001837 | SMap | S_parent | Sequence | CHROMOSOME_X | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | hda-4 | Person_evidence | WBPerson419 | |||||
| Sequence_name | C10E2.3 | ||||||||
| Molecular_name | C10E2.3a | ||||||||
| C10E2.3a.1 | |||||||||
| CE42060 | |||||||||
| C10E2.3b | |||||||||
| CE37192 | |||||||||
| C10E2.3b.1 | |||||||||
| Other_name | hda-7 | ||||||||
| CELE_C10E2.3 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | hda-4 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:25 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | hda | ||||||||
| Allele (213) | |||||||||
| Strain | WBStrain00031136 | ||||||||
| WBStrain00031472 | |||||||||
| WBStrain00030107 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (21) | |||||||||
| Contained_in_operon | CEOPX150 | ||||||||
| Ortholog (46) | |||||||||
| Paralog | WBGene00219378 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00009663 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00018319 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00001838 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00001834 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00001835 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00001836 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00007953 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00009657 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | hda-4 encodes a class II histone deacetylase that contains a putative MEF-2 DNA binding domain, a nuclear localization signal domain, and a single catalytic domain and may affect locomotion, body morphology, and growth; interacts with MEF-2 in in vitro assays and is expressed in body-wall muscle, neurons, and hypodermal seam cells | Paper_evidence | WBPaper00005287 | |||||
| WBPaper00006395 | |||||||||
| WBPaper00019247 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| Date_last_updated | 09 Aug 2004 00:00:00 | ||||||||
| Automated_description | Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in negative regulation of transcription by RNA polymerase II; receptor guanylyl cyclase signaling pathway; and regulation of neuron differentiation. Located in nucleus. Expressed in amphid neurons; body wall musculature; motor neurons; seam cell; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); gastrointestinal system cancer (multiple); and neurodegenerative disease (multiple). Is an ortholog of several human genes including HDAC4 (histone deacetylase 4); HDAC5 (histone deacetylase 5); and HDAC9 (histone deacetylase 9). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (13) | ||||||||
| Molecular_info | Corresponding_CDS | C10E2.3a | |||||||
| C10E2.3b | |||||||||
| Corresponding_CDS_history | C10E2.3:wp129 | ||||||||
| C10E2.3:wp187 | |||||||||
| Corresponding_transcript | C10E2.3a.1 | ||||||||
| C10E2.3b.1 | |||||||||
| Other_sequence (32) | |||||||||
| Associated_feature (13) | |||||||||
| Experimental_info | RNAi_result (15) | ||||||||
| Expr_pattern | Expr1910 | ||||||||
| Expr4398 | |||||||||
| Expr1027688 | |||||||||
| Expr1031082 | |||||||||
| Expr1144370 | |||||||||
| Expr1200369 | |||||||||
| Expr2012387 | |||||||||
| Expr2030623 | |||||||||
| Drives_construct | WBCnstr00005312 | ||||||||
| WBCnstr00010514 | |||||||||
| WBCnstr00011966 | |||||||||
| WBCnstr00036655 | |||||||||
| Construct_product | WBCnstr00005312 | ||||||||
| WBCnstr00010514 | |||||||||
| WBCnstr00011966 | |||||||||
| WBCnstr00036655 | |||||||||
| Antibody | WBAntibody00000521 | ||||||||
| Microarray_results (24) | |||||||||
| Expression_cluster (98) | |||||||||
| Interaction (39) | |||||||||
| Map_info | Map | X | Position | 24.0594 | Error | 0.000499 | |||
| Positive | Positive_clone | C10E2 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4398 | |||||||
| 5059 | |||||||||
| 5309 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (28) | |||||||||
| Remark | Sequence connection from [Choi KY, Ahnn J], 02/06/13 krb. | ||||||||
| Ahnn et al asked for C10E2.3 to be named hda-4, but published it as hda-7 | CGC_data_submission | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
