WormBase Tree Display for Gene: WBGene00001500
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WBGene00001500 | SMap | S_parent | Sequence | C54F6 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | ftn | ||||||
Allele (31) | |||||||
Strain | WBStrain00033278 | ||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (17) | |||||||
Ortholog (69) | |||||||
Paralog | WBGene00001501 | Caenorhabditis elegans | From_analysis | TreeFam | |||
Inparanoid_8 | |||||||
Panther | |||||||
WormBase-Compara | |||||||
Structured_description | Concise_description | ftn-1 encodes one of two C. elegans ferritin heavy chain homologs; ftn-1 activity is essential for normal lifespan under iron stress conditions and, in addition, has been reported to be essential for embryogenesis; an ftn-1::gfp reporter is expressed in the intestine at all stages of development and its expression, as well as that of ftn-1 mRNA, increases under iron stress conditions and in the background of mutations in the second ferritin-encoding gene, ftn-2. | Paper_evidence | WBPaper00005703 | |||
WBPaper00024456 | |||||||
WBPaper00024497 | |||||||
Curator_confirmed | WBPerson48 | ||||||
WBPerson1843 | |||||||
Date_last_updated | 10 Mar 2006 00:00:00 | ||||||
Automated_description | Enables identical protein binding activity. Involved in intracellular iron ion homeostasis. Predicted to be located in cytoplasm. Expressed in intestine and pharyngeal-intestinal valve. Human ortholog(s) of this gene implicated in several diseases, including hemochromatosis type 5; hyperferritinemia-cataract syndrome; and neurodegeneration with brain iron accumulation 3. Is an ortholog of human FTH1 (ferritin heavy chain 1); FTHL17 (ferritin heavy chain like 17); and FTMT (ferritin mitochondrial). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:0111256 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3999) | ||
DOID:1289 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3999) | ||||
DOID:0111031 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3976) | ||||
DOID:0080600 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3976,HGNC:3999) | ||||
DOID:0110737 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3999) | ||||
DOID:679 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3999) | ||||
Molecular_info | Corresponding_CDS | C54F6.14 | |||||
Corresponding_transcript | C54F6.14.1 | ||||||
Other_sequence (18) | |||||||
Associated_feature (12) | |||||||
Experimental_info | RNAi_result (19) | ||||||
Expr_pattern (10) | |||||||
Drives_construct (20) | |||||||
Construct_product | WBCnstr00011120 | ||||||
WBCnstr00014621 | |||||||
WBCnstr00036908 | |||||||
WBCnstr00041574 | |||||||
WBCnstr00042810 | |||||||
WBCnstr00042811 | |||||||
Antibody | WBAntibody00002946 | ||||||
Microarray_results (17) | |||||||
Expression_cluster (363) | |||||||
Interaction (217) | |||||||
WBProcess | WBbiopr:00000096 | ||||||
Map_info | Map | V | Position | 0.786806 | Error | 0.005591 | |
Positive | Positive_clone | C54F6 | Inferred_automatically | From CDS info | |||
From sequence, transcript, pseudogene data | |||||||
Pseudo_map_position | |||||||
Reference (42) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |