WormBase Tree Display for Gene: WBGene00001395
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WBGene00001395 | SMap | S_parent | Sequence | CHROMOSOME_IV | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | fat | ||||||
Allele (56) | |||||||
Legacy_information | [Barnes TM] fat for FATty acid metabolism. Encodes predicted enzyme for beta-oxidation of fatty acids. Predicted gene C17G10.8 | ||||||
Strain | WBStrain00036068 | ||||||
WBStrain00004012 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (30) | |||||||
Ortholog (41) | |||||||
Paralog | WBGene00001396 | Caenorhabditis elegans | From_analysis | Panther | |||
WormBase-Compara | |||||||
Structured_description | Concise_description | fat-3 encodes a delta-6 fatty acid desaturase ('linoleoyl-CoA desaturase') containing an N-terminal cytochrome b5 domain that is orthologous to the vertebrate fatty acid desaturases (FADS); FAT-3 expressed in yeast uses linoleic and alpha-linolenic acid as substrates; FAT-3 is absolutely required in vivo for synthesis of delta-6 fatty acids, and also required for fully normal synthesis of C20 fatty acids; FAT-3 is required for a normally fast growth rate and movement speed, and for normal defecation rhythms and fertility; fat-3 is also required for regulation of basal innate immunity. | Paper_evidence | WBPaper00003032 | |||
WBPaper00003387 | |||||||
WBPaper00003999 | |||||||
WBPaper00005233 | |||||||
WBPaper00005728 | |||||||
WBPaper00013538 | |||||||
WBPaper00013550 | |||||||
WBPaper00013584 | |||||||
WBPaper00032370 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson567 | |||||||
Date_last_updated | 16 May 2014 00:00:00 | ||||||
Automated_description | Enables stearoyl-CoA 9-desaturase activity. Involved in several processes, including egg-laying behavior; signal release; and system process. Predicted to be located in membrane. Expressed in body wall musculature; head neurons; intestine; pharynx; and tail neurons. Used to study alcohol use disorder and lipid metabolism disorder. Is an ortholog of human FADS2 (fatty acid desaturase 2) and FADS3 (fatty acid desaturase 3). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Experimental_model | DOID:1574 | Homo sapiens | Paper_evidence | WBPaper00045655 | ||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 05 Jun 2019 00:00:00 | ||||||
DOID:3146 | Homo sapiens | Paper_evidence | WBPaper00060352 | ||||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 21 Jan 2021 00:00:00 | ||||||
Potential_model | DOID:12930 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3575) | |||
Models_disease_asserted | WBDOannot00000699 | ||||||
WBDOannot00000845 | |||||||
Molecular_info | Corresponding_CDS | W08D2.4a | |||||
W08D2.4b | |||||||
W08D2.4c | |||||||
W08D2.4d | |||||||
Corresponding_transcript | W08D2.4a.1 | ||||||
W08D2.4b.1 | |||||||
W08D2.4c.1 | |||||||
W08D2.4d.1 | |||||||
Other_sequence (97) | |||||||
Associated_feature | WBsf646256 | ||||||
WBsf660531 | |||||||
WBsf660532 | |||||||
WBsf978983 | |||||||
WBsf228878 | |||||||
Experimental_info (9) | |||||||
Map_info | Map | IV | Position | 4.42122 | Error | 0.000463 | |
Positive | Positive_clone | W08D2 | Person_evidence | WBPerson681 | |||
Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
Mapping_data | Multi_point | 4299 | |||||
4300 | |||||||
Pseudo_map_position | |||||||
Reference (82) | |||||||
Remark | C17G10.8 link removed by agreement [sdm 0107] | ||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||
Method | Gene |