WormBase Tree Display for Gene: WBGene00001032
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WBGene00001032 | SMap | S_parent | Sequence | K02G10 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | dnj-14 | Person_evidence | WBPerson625 | |||||
Sequence_name | K02G10.8 | ||||||||
Molecular_name | K02G10.8a | ||||||||
K02G10.8a.1 | |||||||||
CE04708 | |||||||||
K02G10.8b | |||||||||
CE45638 | |||||||||
K02G10.8b.1 | |||||||||
Other_name | CELE_K02G10.8 | Accession_evidence | NDB | BX284606 | |||||
Public_name | dnj-14 | ||||||||
DB_info | Database (11) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:22 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info (10) | |||||||||
Disease_info | Experimental_model | DOID:14503 | Homo sapiens | Paper_evidence | WBPaper00045410 | ||||
Accession_evidence | OMIM | 162350 | |||||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 24 Apr 2017 00:00:00 | ||||||||
Potential_model | DOID:0110720 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:16235) | |||||
Disease_relevance | Mutations in human DNAJC5 are implicated in adult onset neuronal lipofuscinosis (ANCL; Kufs disease and Parry disease), a neurodegenerative disorder characterised by progressive neuronal dysfunction and premature death; DNAJC5 encodes an evolutionarily conserved member of the DnaJ/Hsp40 family of molecular chaperones known as cysteine string protein (CSP); in C. elegans, mutants of dnj-14 (tm3223, ok237), which is orthologous to human DNAJC5, show reduced life-span, impaired locomotion, reduced neurotransmission and impaired chemosensation; older dnj-14 animals exhibited neuronal abnormalities like loss of neuronal cell bodies, reduction in the number of visible neurites, and the presence of contorted neuronal processes; use of this dnj-14 model identified resveratrol as a compound that could extend dnj-14 mutant lifespan, partially rescue the neurodegeneration phenotype and significantly ameliorate the chemotaxis defects of dnj-14 mutants; this resveratrol activity was mimicked by phosphodiesterase inhibition and independent of SIR-2.1/Sirtuin, unlike in other C. elegans neurodegeneration models where resveratrol activity was shown to be sir-2.1 dependent. | Homo sapiens | Paper_evidence | WBPaper00045410 | |||||
Accession_evidence | OMIM | 611203 | |||||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 24 Apr 2017 00:00:00 | ||||||||
Models_disease_asserted | WBDOannot00000331 | ||||||||
WBDOannot00000409 | |||||||||
WBDOannot00000410 | |||||||||
Molecular_info | Corresponding_CDS | K02G10.8a | |||||||
K02G10.8b | |||||||||
Corresponding_transcript | K02G10.8a.1 | ||||||||
K02G10.8b.1 | |||||||||
Other_sequence (30) | |||||||||
Associated_feature | WBsf653929 | ||||||||
WBsf670453 | |||||||||
WBsf982161 | |||||||||
WBsf237308 | |||||||||
WBsf237309 | |||||||||
WBsf237310 | |||||||||
WBsf237311 | |||||||||
Experimental_info | RNAi_result | WBRNAi00016500 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00106560 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00106561 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00106329 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00033900 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00076542 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00049772 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern | Expr1021089 | ||||||||
Expr1030644 | |||||||||
Expr1153487 | |||||||||
Expr2010988 | |||||||||
Expr2029226 | |||||||||
Drives_construct | WBCnstr00042947 | ||||||||
Regulate_expr_cluster | WBPaper00048567:dnj-14_downregulated | ||||||||
WBPaper00048567:dnj-14_upregulated | |||||||||
Microarray_results (28) | |||||||||
Expression_cluster (120) | |||||||||
Interaction (44) | |||||||||
Map_info | Map | X | Position | -6.83097 | Error | 0.016329 | |||
Positive | Positive_clone | K02G10 | Inferred_automatically (2) | ||||||
Mapping_data | Multi_point | 4264 | |||||||
5084 | |||||||||
5264 | |||||||||
Pseudo_map_position | |||||||||
Reference (14) | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |