WormBase Tree Display for Gene: WBGene00000156
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WBGene00000156 | SMap | S_parent | Sequence | K04G2 | ||
---|---|---|---|---|---|---|
Identity (6) | ||||||
Gene_info | Biotype | SO:0001217 | ||||
Gene_class | apr | |||||
Allele (69) | ||||||
Possibly_affected_by | WBVar02153202 | |||||
Legacy_information | [Rocheleau CE] apr-1 for APC (adenomatous polyposis coli) Related gene. No mutants known, 26% of apr-1(RNAi) embryos lack endoderm, overproduce pharyngeal tissue, E divides prematurely, adopts MS-like fate. Predicted gene K04G2.8. Allele zh10 isolated, see below. [sdm 12/01] | |||||
Strain | WBStrain00037280 | |||||
WBStrain00000140 | ||||||
WBStrain00008585 | ||||||
WBStrain00024309 | ||||||
RNASeq_FPKM (74) | ||||||
GO_annotation (77) | ||||||
Ortholog (41) | ||||||
Structured_description | Concise_description | The apr-1 gene encodes an ortholog of human APC (OMIM:175100, mutated in familial adenomatous polyposis) that is required for germline fertility, the control of homeodomain expression (CEH-13 and LIN-39) during embryogenesis and vulval development, and for the migration and elongation of hypodermal cells during embryo morphogenesis; APR-1 is thought to reside in adherens junctions, while also stimulating two beta-catenins in Wnt signalling (HMP-2 in migrating epithelial cells, and BAR-1 in the vulval precursor cells); however, APR-1 also binds PRY-1/axin, and with PRY-1 inhibits RAS-independent Wnt induction of LIN-39; APR-1 along with MOM-5/Frizzled receptor and GSK-3 kinase is also required for the engulfment of apoptotic cells and migration of the distal tip cell in the gonad, indicating that Wnt signaling can regulate cytoskeletal rearrangements via CED-10/RAC; phosphorylated APR-1 binds CED-2/CrkII in yeast two hybrid screens, this binding and genetic studies suggest that APR-1 and MOM-5 activate the CED-2/5/12 branch of the engulfment pathway. | Paper_evidence (12) | |||
Curator_confirmed | WBPerson324 | |||||
WBPerson567 | ||||||
Date_last_updated | 25 May 2011 00:00:00 | |||||
Automated_description | Enables beta-catenin binding activity. Involved in several processes, including embryonic morphogenesis; regulation of Wnt signaling pathway; and regulation of multicellular organismal development. Located in adherens junction; cell cortex; and nucleus. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P8.p hermaphrodite; distal tip cell; and excretory cell. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Sotos syndrome 3; carcinoma (multiple); and gastrointestinal system cancer (multiple). Is an ortholog of human APC (APC regulator of WNT signaling pathway) and APC2 (APC regulator of WNT signaling pathway 2). | Paper_evidence | WBPaper00065943 | |||
Curator_confirmed | WBPerson324 | |||||
WBPerson37462 | ||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | |||||
Date_last_updated | 29 Nov 2023 00:00:00 | |||||
Disease_info | Potential_model (20) | |||||
Molecular_info | Corresponding_CDS | K04G2.8a | ||||
K04G2.8b | ||||||
K04G2.8c | ||||||
Corresponding_transcript | K04G2.8a.1 | |||||
K04G2.8b.1 | ||||||
K04G2.8c.1 | ||||||
Other_sequence | AF013950 | |||||
CGC00612_1 | ||||||
ACC25655_1 | ||||||
EX555243.1 | ||||||
CBC06635_1 | ||||||
Associated_feature | WBsf656598 | |||||
WBsf218114 | ||||||
Experimental_info | RNAi_result (104) | |||||
Expr_pattern | Expr1046 | |||||
Expr4600 | ||||||
Expr12119 | ||||||
Expr12448 | ||||||
Expr15118 | ||||||
Expr1028112 | ||||||
Expr1030085 | ||||||
Expr1153646 | ||||||
Expr2009365 | ||||||
Expr2027601 | ||||||
Drives_construct | WBCnstr00005188 | |||||
WBCnstr00007256 | ||||||
WBCnstr00009075 | ||||||
WBCnstr00009116 | ||||||
WBCnstr00012108 | ||||||
WBCnstr00016098 | ||||||
WBCnstr00020198 | ||||||
WBCnstr00021087 | ||||||
WBCnstr00037698 | ||||||
Construct_product | WBCnstr00000526 | |||||
WBCnstr00007257 | ||||||
WBCnstr00007258 | ||||||
WBCnstr00009057 | ||||||
WBCnstr00009075 | ||||||
WBCnstr00012108 | ||||||
WBCnstr00016098 | ||||||
WBCnstr00020198 | ||||||
WBCnstr00021087 | ||||||
WBCnstr00037698 | ||||||
Antibody | WBAntibody00000276 | |||||
WBAntibody00000277 | ||||||
Microarray_results (25) | ||||||
Expression_cluster (124) | ||||||
Interaction (179) | ||||||
WBProcess | WBbiopr:00000073 | |||||
Map_info (4) | ||||||
Reference (108) | ||||||
Picture | WBPicture0000013084 | |||||
Remark | Data extracted from Rocheleau et al. (1997) | |||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |