WormBase Tree Display for Gene: WBGene00000156
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WBGene00000156 | SMap | S_parent | Sequence | K04G2 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | apr | ||||||
Allele (69) | |||||||
Possibly_affected_by | WBVar02153202 | ||||||
Legacy_information | [Rocheleau CE] apr-1 for APC (adenomatous polyposis coli) Related gene. No mutants known, 26% of apr-1(RNAi) embryos lack endoderm, overproduce pharyngeal tissue, E divides prematurely, adopts MS-like fate. Predicted gene K04G2.8. Allele zh10 isolated, see below. [sdm 12/01] | ||||||
Strain | WBStrain00037280 | ||||||
WBStrain00000140 | |||||||
WBStrain00008585 | |||||||
WBStrain00024309 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (77) | |||||||
Ortholog (41) | |||||||
Structured_description | Concise_description | The apr-1 gene encodes an ortholog of human APC (OMIM:175100, mutated in familial adenomatous polyposis) that is required for germline fertility, the control of homeodomain expression (CEH-13 and LIN-39) during embryogenesis and vulval development, and for the migration and elongation of hypodermal cells during embryo morphogenesis; APR-1 is thought to reside in adherens junctions, while also stimulating two beta-catenins in Wnt signalling (HMP-2 in migrating epithelial cells, and BAR-1 in the vulval precursor cells); however, APR-1 also binds PRY-1/axin, and with PRY-1 inhibits RAS-independent Wnt induction of LIN-39; APR-1 along with MOM-5/Frizzled receptor and GSK-3 kinase is also required for the engulfment of apoptotic cells and migration of the distal tip cell in the gonad, indicating that Wnt signaling can regulate cytoskeletal rearrangements via CED-10/RAC; phosphorylated APR-1 binds CED-2/CrkII in yeast two hybrid screens, this binding and genetic studies suggest that APR-1 and MOM-5 activate the CED-2/5/12 branch of the engulfment pathway. | Paper_evidence (12) | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson567 | |||||||
Date_last_updated | 25 May 2011 00:00:00 | ||||||
Automated_description | Enables beta-catenin binding activity. Involved in several processes, including embryonic morphogenesis; regulation of Wnt signaling pathway; and regulation of multicellular organismal development. Located in adherens junction; cell cortex; and nucleus. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P8.p hermaphrodite; distal tip cell; and excretory cell. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Sotos syndrome 3; carcinoma (multiple); and gastrointestinal system cancer (multiple). Is an ortholog of human APC (APC regulator of WNT signaling pathway) and APC2 (APC regulator of WNT signaling pathway 2). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model (20) | ||||||
Molecular_info (4) | |||||||
Experimental_info | RNAi_result (104) | ||||||
Expr_pattern (10) | |||||||
Drives_construct | WBCnstr00005188 | ||||||
WBCnstr00007256 | |||||||
WBCnstr00009075 | |||||||
WBCnstr00009116 | |||||||
WBCnstr00012108 | |||||||
WBCnstr00016098 | |||||||
WBCnstr00020198 | |||||||
WBCnstr00021087 | |||||||
WBCnstr00037698 | |||||||
Construct_product | WBCnstr00000526 | ||||||
WBCnstr00007257 | |||||||
WBCnstr00007258 | |||||||
WBCnstr00009057 | |||||||
WBCnstr00009075 | |||||||
WBCnstr00012108 | |||||||
WBCnstr00016098 | |||||||
WBCnstr00020198 | |||||||
WBCnstr00021087 | |||||||
WBCnstr00037698 | |||||||
Antibody | WBAntibody00000276 | ||||||
WBAntibody00000277 | |||||||
Microarray_results (25) | |||||||
Expression_cluster (124) | |||||||
Interaction (179) | |||||||
WBProcess | WBbiopr:00000073 | ||||||
Map_info | Map | I | Position | 2.43771 | Error | 0.002342 | |
Positive | Positive_clone | K04G2 | Person_evidence | WBPerson524 | |||
Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
Mapping_data | Multi_point | 4159 | |||||
4893 | |||||||
5616 | |||||||
Pseudo_map_position | |||||||
Reference (108) | |||||||
Picture | WBPicture0000013084 | ||||||
Remark | Data extracted from Rocheleau et al. (1997) | ||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||
Method | Gene |