WormBase Tree Display for Gene: WBGene00000143
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WBGene00000143 | SMap | S_parent | Sequence | K06H7 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | apc-2 | Person_evidence | WBPerson205 | |||||
Sequence_name | K06H7.6 | ||||||||
Molecular_name | K06H7.6 | ||||||||
K06H7.6.1 | |||||||||
CE41679 | |||||||||
Other_name | CELE_K06H7.6 | Accession_evidence | NDB | BX284603 | |||||
Public_name | apc-2 | ||||||||
DB_info | Database (10) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | apc | ||||||||
Allele (32) | |||||||||
Strain | WBStrain00036412 | ||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (11) | |||||||||
Ortholog (35) | |||||||||
Paralog | WBGene00000836 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
WBGene00000837 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
WBGene00000838 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
WBGene00000839 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
WBGene00000840 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
WBGene00000841 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
Structured_description | Concise_description | apc-2 encodes an ortholog of subunit 2 of anaphase-promoting complex (APC,a cyclin-specific E3 RING ubiquitin ligase); APC-2 and S. cerevisiae'sApc2p have 32% identity in their cullin domains (considered crucial forfunction), but otherwise share no obvious similarity; inactivating apc-2with RNAi causes embryos to arrest at the meiotic one-cell stage, implyingthat APC-2 is required for the metaphase-to-anaphase transition of meiosisI; this RNAi phenotype of apc-2 is shared by apc-1, apc-4, apc-11, cdc-16,cdc-23, and cdc-27; by analogy with other APC subunits with hypomorphicalleles, APC-2 is likely to be required for asymmetrical segregation ofcell fate determinants in two-cell embryos. | Paper_evidence | WBPaper00005096 | |||||
WBPaper00013611 | |||||||||
WBPaper00027095 | |||||||||
WBPaper00028289 | |||||||||
Curator_confirmed | WBPerson567 | ||||||||
Date_last_updated | 09 Aug 2006 00:00:00 | ||||||||
Automated_description | Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in metaphase/anaphase transition of mitotic cell cycle and protein K11-linked ubiquitination. Predicted to be part of anaphase-promoting complex. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; lung disease (multiple); and primary angle-closure glaucoma. Is an ortholog of human ANAPC2 (anaphase promoting complex subunit 2). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:5386 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:19989) | ||||
DOID:3910 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:19989) | ||||||
DOID:12449 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:19989) | ||||||
DOID:1405 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:19989) | ||||||
DOID:9119 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:19989) | ||||||
Molecular_info | Corresponding_CDS | K06H7.6 | |||||||
Corresponding_CDS_history | K06H7.6:wp183 | ||||||||
Corresponding_transcript | K06H7.6.1 | ||||||||
Other_sequence (18) | |||||||||
Associated_feature | WBsf645383 | ||||||||
WBsf645384 | |||||||||
WBsf659223 | |||||||||
WBsf225339 | |||||||||
Experimental_info | RNAi_result (16) | ||||||||
Expr_pattern | Expr1017011 | ||||||||
Expr1030075 | |||||||||
Expr1153776 | |||||||||
Expr2009354 | |||||||||
Expr2027590 | |||||||||
Drives_construct | WBCnstr00037708 | ||||||||
Construct_product | WBCnstr00037708 | ||||||||
Microarray_results (22) | |||||||||
Expression_cluster (116) | |||||||||
Interaction (218) | |||||||||
Map_info | Map | III | Position | -0.383689 | Error | 0.000955 | |||
Positive | Positive_clone | K06H7 | Inferred_automatically | From CDS info | |||||
From sequence, transcript, pseudogene data | |||||||||
Pseudo_map_position | |||||||||
Reference | WBPaper00031064 | ||||||||
WBPaper00035228 | |||||||||
WBPaper00038491 | |||||||||
WBPaper00055090 | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |