WormBase Tree Display for Gene: HGNC:2865

HGNC:2865 Identity: Name: CGC_name: Dhh Inferred_automatically: AGR_import
      Other_name: RGD:1345874
        GDMN
        GDXYM
        HHG-3
        MGC35145
        SRXY7
        desert hedgehog
        desert hedgehog homolog
        desert hedgehog protein
        mutant desert hedgehog
      Public_name: Dhh
    DB_info: Database: HGNC id 2865
        AGR cURI HGNC:2865
        EnsEMBL ENSEMBL_geneID ENSG00000139549
        UniProt UniProt_AC O43323
        OMIM gene 605423
        DO id DOID:14448
            DOID:0111774
    Species: Homo sapiens
    Status: Live
  Gene_info: Biotype: SO:0001217
    Ortholog: WBGene00001691 Caenorhabditis elegans From_analysis: EnsEMBL-Compara
            OrthoInspector
            SonicParanoid
      WBGene00001700 Caenorhabditis elegans From_analysis: EnsEMBL-Compara
            OrthoInspector
            SonicParanoid
    Structured_description: Automated_description: This gene encodes a member of the hedgehog family. The hedgehog gene family encodes signaling molecules that play an important role in regulating morphogenesis. This protein is predicted to be made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the organism. Defects in this protein have been associated with partial gonadal dysgenesis (PGD) accompanied by minifascicular polyneuropathy. This protein may be involved in both male gonadal differentiation and perineurial development. [provided by RefSeq, May 2010] Inferred_automatically: AGR_import