WormBase Tree Display for Gene: WBGene00001691
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| WBGene00001691 | Evidence | Paper_evidence | WBPaper00003717 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | F46B3 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | grd-2 | Person_evidence | WBPerson83 | |||||
| Sequence_name | F46B3.5 | ||||||||
| Molecular_name | F46B3.5 | ||||||||
| F46B3.5.1 | |||||||||
| CE34022 | |||||||||
| Other_name | CELE_F46B3.5 | Accession_evidence | NDB | BX284605 | |||||
| Public_name | grd-2 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:25 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | grd | ||||||||
| Allele (238) | |||||||||
| Strain | WBStrain00036601 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (11) | |||||||||
| Ortholog (24) | |||||||||
| Paralog (24) | |||||||||
| Structured_description | Concise_description | grd-2 encodes a hedgehog-like protein, with (from N- to C-terminus) asignal sequence, four Ground domains, an short region of low-complexitysequence, and a Hint/Hog domain; the Hint/Hog domain is predicted to cutGRD-2 into two halves and then covalently link cholesterol to theC-terminus of the Ground domain; the four N-terminal Ground domains arepredicted to form one or more cysteine-crosslinked proteins involved inintercellular signalling; Ground domains have subtle similarity to theN-terminal Hedge domain of HEDGEHOG proteins; GRD-2 is weakly requiredfor normal molting; GRD-2 is also required for normal adult alaeformation, growth to full size, locomotion, and male tail development;all of these requirements may reflect common defects incholesterol-dependent hedgehog-like signalling or in vesicletrafficking. | Paper_evidence | WBPaper00002823 | |||||
| WBPaper00003717 | |||||||||
| WBPaper00004651 | |||||||||
| WBPaper00005654 | |||||||||
| WBPaper00026841 | |||||||||
| WBPaper00027263 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 05 Nov 2006 00:00:00 | ||||||||
| Automated_description | Predicted to enable cholesterol binding activity; endopeptidase activity; and signaling receptor binding activity. Acts upstream of or within nematode male tail mating organ morphogenesis. Predicted to be located in extracellular region. Expressed in excretory duct and excretory pore. Human ortholog(s) of this gene implicated in several diseases, including bone disease (multiple); gastrointestinal system cancer (multiple); and glomerulonephritis (multiple). Is an ortholog of human DHH (desert hedgehog signaling molecule); IHH (Indian hedgehog signaling molecule); and SHH (sonic hedgehog signaling molecule). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (30) | ||||||||
| Molecular_info | Corresponding_CDS | F46B3.5 | |||||||
| Corresponding_CDS_history | F46B3.5:wp101 | ||||||||
| Corresponding_transcript | F46B3.5.1 | ||||||||
| Associated_feature | WBsf647750 | ||||||||
| WBsf662249 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00076971 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00076991 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00077016 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00001503 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00089082 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00047486 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00015060 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00032345 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr634 | ||||||||
| Expr4418 | |||||||||
| Expr4430 | |||||||||
| Expr1012477 | |||||||||
| Expr1151323 | |||||||||
| Expr2012232 | |||||||||
| Expr2030468 | |||||||||
| Drives_construct | WBCnstr00011979 | ||||||||
| WBCnstr00011993 | |||||||||
| WBCnstr00012458 | |||||||||
| WBCnstr00036765 | |||||||||
| Construct_product | WBCnstr00036765 | ||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (205) | |||||||||
| Interaction (248) | |||||||||
| WBProcess | WBbiopr:00000123 | ||||||||
| Map_info | Map | V | Position | 25.0256 | Error | 0.000805 | |||
| Positive | Positive_clone | F46B3 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00003717 | ||||||||
| WBPaper00024393 | |||||||||
| WBPaper00026841 | |||||||||
| WBPaper00028754 | |||||||||
| WBPaper00031588 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00062715 | |||||||||
| WBPaper00064105 | |||||||||
| Remark | yk87f2 removed from sequence list . sdm 11/00 | ||||||||
| Contains 4repeats of the Ground domain and one Hog domain | Paper_evidence | WBPaper00003717 | |||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
