WormBase Tree Display for Gene: WBGene00015735
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WBGene00015735 | SMap | S_parent | Sequence | C13B9 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | pdfr | ||||||
Allele (246) | |||||||
Strain (11) | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (31) | |||||||
Ortholog (47) | |||||||
Paralog | WBGene00007664 | Caenorhabditis elegans | From_analysis | TreeFam | |||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00014035 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00002251 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00002252 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00009304 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00017947 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00017948 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
Structured_description | Concise_description | pdfr-1 encodes, by alternative splicing, three isoforms of a G-protein-coupled receptor (GPCR) required for normal locomotion; PDFR-1 is orthologous to Drosophila pigment dispersing factor (PDF) receptors, and to human CALCR (OMIM:114131, associated with susceptibility to osteoporesis); pdfr-1 is expressed in all body wall muscles and many head and tail neurons; the C. elegans neuropeptides PDF-1a, PDF-1b, or PDF-2 (orthologous to Drosophila PDF) activated PDFR-1 receptors with dose-dependent nanomolar potency; in vivo, excess PDF-2 induces a movement phenotype like that seen in a pdf-1 null mutant, indicating that PDF-1a/b and PDF-2 exert opposite effects on PDFR-1. | Paper_evidence | WBPaper00012979 | |||
WBPaper00028902 | |||||||
WBPaper00031656 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson1823 | |||||||
WBPerson567 | |||||||
Date_last_updated | 14 Jul 2008 00:00:00 | ||||||
Automated_description | Enables calcitonin family receptor activity. Involved in several processes, including locomotory behavior; signal transduction; and sleep. Located in plasma membrane. Expressed in several structures, including I1 neuron; RMEV; ganglia; mechanosensory neurons; and vulD. Human ortholog(s) of this gene implicated in bone disease (multiple); hereditary lymphedema; and primary failure of tooth eruption. Is an ortholog of human CALCR (calcitonin receptor); CALCRL (calcitonin receptor like receptor); and PTH1R (parathyroid hormone 1 receptor). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:0080020 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9608) | ||
DOID:0050580 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:16709) | ||||
DOID:0060387 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9608) | ||||
DOID:2256 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9608) | ||||
DOID:0111341 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9608) | ||||
DOID:11476 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1440) | ||||
DOID:0111732 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9608) | ||||
Molecular_info | Corresponding_CDS | C13B9.4a | |||||
C13B9.4b | |||||||
C13B9.4c | |||||||
C13B9.4d | |||||||
C13B9.4e | |||||||
Corresponding_CDS_history | C13B9.4:wp127 | ||||||
Corresponding_transcript (13) | |||||||
Other_sequence (25) | |||||||
Associated_feature (24) | |||||||
Experimental_info | RNAi_result | WBRNAi00010677 | Inferred_automatically | RNAi_primary | |||
WBRNAi00005367 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00027171 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00040427 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00024543 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00024544 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00028838 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern (15) | |||||||
Drives_construct | WBCnstr00002179 | ||||||
WBCnstr00002180 | |||||||
WBCnstr00004248 | |||||||
WBCnstr00004988 | |||||||
WBCnstr00015834 | |||||||
WBCnstr00015836 | |||||||
WBCnstr00019100 | |||||||
WBCnstr00021690 | |||||||
WBCnstr00021702 | |||||||
WBCnstr00028610 | |||||||
Construct_product (12) | |||||||
Antibody | WBAntibody00001399 | ||||||
Microarray_results (36) | |||||||
Expression_cluster (224) | |||||||
Interaction (12) | |||||||
Map_info | Map | III | Position | -1.02511 | Error | 0.00506 | |
Positive | Positive_clone | C13B9 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Pseudo_map_position | |||||||
Reference | WBPaper00010230 | ||||||
WBPaper00012979 | |||||||
WBPaper00018302 | |||||||
WBPaper00019605 | |||||||
WBPaper00028902 | |||||||
WBPaper00031656 | |||||||
WBPaper00034125 | |||||||
WBPaper00035341 | |||||||
WBPaper00038491 | |||||||
WBPaper00039422 | |||||||
WBPaper00041096 | |||||||
WBPaper00041718 | |||||||
WBPaper00042479 | |||||||
WBPaper00043197 | |||||||
WBPaper00043343 | |||||||
WBPaper00043454 | |||||||
WBPaper00044094 | |||||||
WBPaper00047014 | |||||||
WBPaper00047452 | |||||||
WBPaper00047602 | |||||||
WBPaper00047901 | |||||||
WBPaper00051653 | |||||||
WBPaper00054889 | |||||||
WBPaper00055090 | |||||||
WBPaper00055514 | |||||||
WBPaper00057426 | |||||||
WBPaper00061844 | |||||||
WBPaper00062055 | |||||||
WBPaper00062132 | |||||||
WBPaper00062771 | |||||||
WBPaper00063630 | |||||||
WBPaper00063685 | |||||||
WBPaper00063827 | |||||||
WBPaper00063837 | |||||||
WBPaper00063859 | |||||||
WBPaper00065946 | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |