WormBase Tree Display for Gene: WBGene00007918
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WBGene00007918 | SMap | S_parent | Sequence | C34C6 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | sphk | ||||||
Allele (42) | |||||||
Strain | WBStrain00036171 | ||||||
WBStrain00005455 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (47) | |||||||
Contained_in_operon | CEOP2384 | ||||||
Ortholog (43) | |||||||
Paralog | WBGene00020398 | Caenorhabditis elegans | From_analysis | Panther | |||
WormBase-Compara | |||||||
WBGene00018674 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
Structured_description | Concise_description | sphk-1 encodes a sphingosine kinase orhtologous to the mammalian sphingosine kinases (SphK1 and SphK2); SPHK-1 activity is required, primarily in neurons, for promoting neurotransmitter release from synaptic vesicles at neuromuscular junctions; sphk-1 is expressedin the majority of cholinergic and GABAergic neurons, as well as in body wall muscle, intestine, and hypodermis; SPHK-1 localizes to discrete subsynaptic regions at presynaptic terminals; SPHK-1 abundance at presynaptic regions is regulated by a muscarinic signaling pathway that includes the muscarinc acetylcholine receptor GAR-3, the G protein subunit EGL-30, and the Trio Rho/GEF UNC-73. | Paper_evidence | WBPaper00041106 | |||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 24 Oct 2013 00:00:00 | ||||||
Automated_description | Predicted to enable D-erythro-sphingosine kinase activity and acetyltransferase activity. Involved in mitochondrial unfolded protein response; positive regulation of acetylcholine secretion, neurotransmission; and regulation of locomotion. Located in several cellular components, including mitochondrion; neuronal cell body; and presynaptic periactive zone. Expressed in several structures, including body wall musculature; excretory canal; intestine; linker cell; and neurons. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Is an ortholog of human SPHK1 (sphingosine kinase 1) and SPHK2 (sphingosine kinase 2). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:9352 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11240) | ||
Molecular_info | Corresponding_CDS | C34C6.5a | |||||
C34C6.5b | |||||||
C34C6.5c | |||||||
C34C6.5d | |||||||
Corresponding_transcript | C34C6.5a.1 | ||||||
C34C6.5b.1 | |||||||
C34C6.5c.1 | |||||||
C34C6.5d.1 | |||||||
Other_sequence (17) | |||||||
Associated_feature | WBsf650356 | ||||||
WBsf650357 | |||||||
WBsf665256 | |||||||
WBsf717740 | |||||||
WBsf988798 | |||||||
WBsf223536 | |||||||
WBsf223537 | |||||||
Experimental_info | RNAi_result (20) | ||||||
Expr_pattern (11) | |||||||
Drives_construct | WBCnstr00015023 | ||||||
WBCnstr00017093 | |||||||
WBCnstr00017395 | |||||||
WBCnstr00018187 | |||||||
WBCnstr00037865 | |||||||
Construct_product (12) | |||||||
Microarray_results (25) | |||||||
Expression_cluster (84) | |||||||
Interaction (24) | |||||||
Map_info | Map | II | Position | 0.842334 | Error | 0.001708 | |
Positive | Positive_clone | C34C6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | Multi_point | 5162 | |||||
5443 | |||||||
Pseudo_map_position | |||||||
Reference | WBPaper00032243 | ||||||
WBPaper00033113 | |||||||
WBPaper00034090 | |||||||
WBPaper00038491 | |||||||
WBPaper00039245 | |||||||
WBPaper00041106 | |||||||
WBPaper00041549 | |||||||
WBPaper00041824 | |||||||
WBPaper00042257 | |||||||
WBPaper00045387 | |||||||
WBPaper00047500 | |||||||
WBPaper00047634 | |||||||
WBPaper00051175 | |||||||
WBPaper00051646 | |||||||
WBPaper00051714 | |||||||
WBPaper00053153 | |||||||
WBPaper00055002 | |||||||
WBPaper00055090 | |||||||
WBPaper00055220 | |||||||
WBPaper00056283 | |||||||
WBPaper00058973 | |||||||
WBPaper00064731 | |||||||
WBPaper00065849 | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |