WormBase Tree Display for Gene: WBGene00006959

WBGene00006959 SMap: S_parent: Sequence: R74
  Identity: Version: 1
    Name: CGC_name: xbp-1 Person_evidence: WBPerson159
      Sequence_name: R74.3
      Molecular_name: R74.3
        R74.3.1
        CE40514
        R74.3.2
      Other_name: CELE_R74.3 Accession_evidence: NDB BX284603
      Public_name: xbp-1
    DB_info: Database: WormQTL gene WBGene00006959
        WormFlux gene WBGene00006959
        NDB locus_tag CELE_R74.3
        Panther gene CAEEL|WormBase=WBGene00006959|UniProtKB=A0FLQ8
          family PTHR46542
        NCBI gene 175541
        RefSeq protein NM_001083177.4
        SwissProt UniProtAcc G5EE07
        UniProt_GCRP UniProtAcc G5EE07
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:44 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: xbp
    Allele (18)
    Possibly_affected_by: WBVar02153517
      WBVar02153518
      WBVar02153519
    Strain: WBStrain00034061
    RNASeq_FPKM (74)
    GO_annotation (37)
    Contained_in_operon: CEOP3865
    Ortholog (25)
    Structured_description: Concise_description: xbp-1 encodes a bZIP transcription factor orthologous to yeast Hac1 and mammalian X box-binding protein 1 (XBP-1, OMIM:194355); XBP-1 is required for the unfolded protein response (UPR) that counteracts cellular stress induced by accumulation of unfolded proteins in the endoplasmic reticulum (ER); xbp-1 mRNA is spliced by the IRE-1 endoribonuclease to promote translation of transcriptionally active XBP-1 that positively regulates UPR gene expression to maintain ER homeostasis and promote normal development; loss of xbp-1 activity also results in near-complete loss of myo-2 pharnygeal myosin expression, although pharyngeal muscle is still present. Paper_evidence (5)
          Curator_confirmed: WBPerson1843
          Date_last_updated: 16 Nov 2011 00:00:00
      Automated_description: Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including defense response to Gram-negative bacterium; determination of adult lifespan; and response to endoplasmic reticulum stress. Predicted to be located in nucleus. Expressed widely. Is an ortholog of human XBP1 (X-box binding protein 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Modifies_disease: DOID:10652
  Modifies_disease_in_annotation: WBDOannot00000237
  Molecular_info: Corresponding_CDS: R74.3
    Corresponding_CDS_history: R74.3:wp166
      R74.3a:wp275
      R74.3c:wp275
    Corresponding_transcript: R74.3.1
      R74.3.2
    Other_sequence (21)
    Associated_feature (16)
    Gene_product_binds: WBsf019101
    Transcription_factor: WBTranscriptionFactor000096
  Experimental_info: RNAi_result (50)
    Expr_pattern: Expr3424
      Expr4095
      Expr7648
      Expr1017530
      Expr1032970
      Expr1155684
      Expr2018089
      Expr2036227
    Drives_construct: WBCnstr00011392
      WBCnstr00012793
      WBCnstr00034070
    Construct_product (11)
    Regulate_expr_cluster: WBPaper00005432:xbp-1(zc12)_downregulated
      WBPaper00005432:xbp-1(zc12)_upregulated
      WBPaper00059175:hlh-17p-XBP-1_downregulated
      WBPaper00059175:hlh-17p-XBP-1_upregulated
    Antibody: WBAntibody00001600
    Microarray_results (30)
    Expression_cluster (170)
    Interaction (117)
    WBProcess: WBbiopr:00000039
      WBbiopr:00000046
      WBbiopr:00000050
      WBbiopr:00000079
  Map_info: Map: III Position: -3.69579 Error: 0.005385
    Positive: Positive_clone: R74 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 5012
        4785
    Pseudo_map_position
  Reference: WBPaper00005036
    WBPaper00005044
    WBPaper00005432
    WBPaper00010764
    WBPaper00019389
    WBPaper00024285
    WBPaper00025202
    WBPaper00025545
    WBPaper00026830
    WBPaper00027274
    WBPaper00027281
    WBPaper00027309
    WBPaper00028704
    WBPaper00029196
    WBPaper00030877
    WBPaper00030887
    WBPaper00030999
    WBPaper00031111
    WBPaper00031857
    WBPaper00032255
    WBPaper00032443
    WBPaper00032521
    WBPaper00033126
    WBPaper00033458
    WBPaper00033757
    WBPaper00033783
    WBPaper00035302
    WBPaper00036008
    WBPaper00036256
    WBPaper00036299
    WBPaper00037064
    WBPaper00037424
    WBPaper00037558
    WBPaper00037586
    WBPaper00038304
    WBPaper00038491
    WBPaper00039618
    WBPaper00039701
    WBPaper00039975
    WBPaper00040082
    WBPaper00040399
    WBPaper00040453
    WBPaper00041512
    WBPaper00042060
    WBPaper00042360
    WBPaper00042524
    WBPaper00043017
    WBPaper00043080
    WBPaper00043174
    WBPaper00043885
    WBPaper00043918
    WBPaper00044211
    WBPaper00044245
    WBPaper00044518
    WBPaper00044794
    WBPaper00045007
    WBPaper00045096
    WBPaper00045460
    WBPaper00045520
    WBPaper00045698
    WBPaper00045849
    WBPaper00045855
    WBPaper00045919
    WBPaper00045971
    WBPaper00046035
    WBPaper00046051
    WBPaper00046107
    WBPaper00046635
    WBPaper00046692
    WBPaper00047656
    WBPaper00048185
    WBPaper00049237
    WBPaper00049307
    WBPaper00049416
    WBPaper00049705
    WBPaper00050679
    WBPaper00050853
    WBPaper00051473
    WBPaper00051582
    WBPaper00051670
    WBPaper00051704
    WBPaper00052338
    WBPaper00052750
    WBPaper00052970
    WBPaper00052972
    WBPaper00053292
    WBPaper00053413
    WBPaper00054840
    WBPaper00055090
    WBPaper00055323
    WBPaper00055424
    WBPaper00055482
    WBPaper00057035
    WBPaper00057059
    WBPaper00057904
    WBPaper00058447
    WBPaper00058463
    WBPaper00058677
    WBPaper00058971
    WBPaper00058976
    WBPaper00059347
    WBPaper00059950
    WBPaper00060283
    WBPaper00060332
    WBPaper00060384
    WBPaper00060420
    WBPaper00060449
    WBPaper00060655
    WBPaper00060933
    WBPaper00060970
    WBPaper00061067
    WBPaper00061323
    WBPaper00061726
    WBPaper00061805
    WBPaper00062528
    WBPaper00063962
    WBPaper00064105
    WBPaper00064142
    WBPaper00064287
    WBPaper00064315
    WBPaper00064684
    WBPaper00064728
    WBPaper00064934
    WBPaper00065116
    WBPaper00065133
    WBPaper00065565
    WBPaper00065621
    WBPaper00065802
    WBPaper00065806
    WBPaper00065841
    WBPaper00066133
    WBPaper00066178
  Remark: Sequence connection from [Ron D]. krb 14/11/01
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene