WormBase Tree Display for Gene: WBGene00006575

WBGene00006575 SMap: S_parent: Sequence: F13B10
  Identity: Version: 2
    Name: CGC_name: tir-1 Person_evidence: WBPerson168
      Sequence_name: F13B10.1
      Molecular_name (29)
      Other_name: nsy-2 Paper_evidence: WBPaper00024676
          Person_evidence: WBPerson42
        CELE_F13B10.1 Accession_evidence: NDB BX284603
      Public_name: tir-1
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History (2)
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: tir
    Allele (424)
    Possibly_affected_by: WBVar02152927
    Strain: WBStrain00031789
      WBStrain00032827
      WBStrain00035844
      WBStrain00040806
      WBStrain00005265
      WBStrain00021983
      WBStrain00021984
    RNASeq_FPKM (74)
    GO_annotation (53)
    Ortholog (53)
    Structured_description: Concise_description: tir-1 encodes a Toll-Interleukin 1 Receptor (TIR) domain adaptor protein that is the C. elegans ortholog of human SARM (sterile alpha and armadillo repeats); tir-1 is required for innate immunity, as loss of tir-1 activity results in increased susceptibility to infection; tir-1 also functions in a lateral signaling pathway that specifies neuronal identity and is required for proper localization of NSY-1/MAPKKK to post-synaptic regions; TIR-1 physically interacts with a number of proteins, including UNC-43/CaMKII, the RAB-1 GTPase, and the ATP synthase f subunit encoded by R53.4; TIR-1 is expressed in neurons and localizes to post-synaptic regions of axons. Paper_evidence: WBPaper00004589
            WBPaper00006488
            WBPaper00006511
            WBPaper00024676
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 22 Mar 2013 00:00:00
      Automated_description: Enables several functions, including NAD+ nucleosidase activity; enzyme binding activity; and identical protein binding activity. Involved in several processes, including NAD catabolic process; defense response to other organism; and regulation of gene expression. Acts upstream of or within serotonin biosynthetic process. Located in axon cytoplasm and cell body. Expressed in head. Used to study amyotrophic lateral sclerosis. Is an ortholog of human SARM1 (sterile alpha and TIR motif containing 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:332 Homo sapiens Paper_evidence: WBPaper00046914
          Curator_confirmed: WBPerson324
          Date_last_updated: 15 Jul 2015 00:00:00
  Models_disease_in_annotation: WBDOannot00000352
  Molecular_info: Corresponding_CDS: F13B10.1a
      F13B10.1b
      F13B10.1c
      F13B10.1d
      F13B10.1e
      F13B10.1f
      F13B10.1g
      F13B10.1h
    Corresponding_CDS_history: F13B10.1c:wp248
    Corresponding_transcript (13)
    Other_sequence (45)
    Associated_feature (48)
  Experimental_info: RNAi_result (53)
    Expr_pattern: Expr3964
      Expr3965
      Expr5747
      Expr14886
      Expr1025922
      Expr1032710
      Expr1148422
      Expr2017410
      Expr2035549
    Drives_construct: WBCnstr00002582
      WBCnstr00006461
    Construct_product (18)
    Antibody: WBAntibody00001006
      WBAntibody00001007
    Microarray_results (57)
    Expression_cluster (277)
    Interaction (168)
    WBProcess: WBbiopr:00000001
      WBbiopr:00000008
      WBbiopr:00000014
      WBbiopr:00000039
  Map_info: Map: III Position: -4.2469 Error: 0.000352
    Positive: Positive_clone: F13B10 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4791
        5662
      Pos_neg_data: 10953
        10954
        10955
    Pseudo_map_position
  Reference: WBPaper00003760
    WBPaper00004692
    WBPaper00006052
    WBPaper00006488
    WBPaper00006511
    WBPaper00006512
    WBPaper00016621
    WBPaper00016967
    WBPaper00017112
    WBPaper00019278
    WBPaper00024131
    WBPaper00024676
    WBPaper00025180
    WBPaper00025467
    WBPaper00025564
    WBPaper00026814
    WBPaper00026883
    WBPaper00027295
    WBPaper00027296
    WBPaper00027588
    WBPaper00028339
    WBPaper00028384
    WBPaper00029015
    WBPaper00029404
    WBPaper00029437
    WBPaper00029438
    WBPaper00031023
    WBPaper00031175
    WBPaper00031666
    WBPaper00031865
    WBPaper00032031
    WBPaper00032445
    WBPaper00032602
    WBPaper00032620
    WBPaper00032658
    WBPaper00032891
    WBPaper00033094
    WBPaper00033778
    WBPaper00034858
    WBPaper00035314
    WBPaper00035315
    WBPaper00036086
    WBPaper00037194
    WBPaper00037270
    WBPaper00037421
    WBPaper00037496
    WBPaper00037959
    WBPaper00038491
    WBPaper00038825
    WBPaper00039042
    WBPaper00039226
    WBPaper00039901
    WBPaper00040621
    WBPaper00040855
    WBPaper00041087
    WBPaper00041101
    WBPaper00041411
    WBPaper00041720
    WBPaper00041897
    WBPaper00042139
    WBPaper00042367
    WBPaper00043321
    WBPaper00043500
    WBPaper00043679
    WBPaper00043840
    WBPaper00044621
    WBPaper00045711
    WBPaper00046373
    WBPaper00046464
    WBPaper00046914
    WBPaper00047453
    WBPaper00047828
    WBPaper00048667
    WBPaper00049085
    WBPaper00049307
    WBPaper00049531
    WBPaper00050338
    WBPaper00051074
    WBPaper00052308
    WBPaper00052488
    WBPaper00052594
    WBPaper00052601
    WBPaper00052889
    WBPaper00053095
    WBPaper00054441
    WBPaper00055090
    WBPaper00056945
    WBPaper00057469
    WBPaper00058289
    WBPaper00058595
    WBPaper00059609
    WBPaper00059843
    WBPaper00060754
    WBPaper00061567
    WBPaper00061641
    WBPaper00061669
    WBPaper00061730
    WBPaper00061774
    WBPaper00062446
    WBPaper00062465
    WBPaper00062602
    WBPaper00062772
    WBPaper00062773
    WBPaper00063571
    WBPaper00064105
    WBPaper00064229
    WBPaper00064255
    WBPaper00064515
    WBPaper00064630
    WBPaper00064670
    WBPaper00065156
    WBPaper00065298
    WBPaper00065558
    WBPaper00065625
    WBPaper00065645
    WBPaper00065681
    WBPaper00065718
    WBPaper00065760
    WBPaper00065833
    WBPaper00065933
    WBPaper00066073
    WBPaper00066076
  Picture: WBPicture0000013079
    WBPicture0000013081
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene