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WormBase Tree Display for Gene: WBGene00006496

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Name Class

WBGene00006496SMapS_parentSequenceCHROMOSOME_X
IdentityVersion6
NameCGC_namecgef-1Person_evidenceWBPerson3190
Sequence_nameC14A11.3
Molecular_nameC14A11.3a
C14A11.3a.1
CE08151
C14A11.3b
CE47800
C14A11.3c
CE41760
C14A11.3b.1
C14A11.3c.1
Other_nametag-150Person_evidenceWBPerson201
CELE_C14A11.3Accession_evidenceNDBBX284606
Public_namecgef-1
DB_infoDatabaseAceViewgeneXD417
WormQTLgeneWBGene00006496
WormFluxgeneWBGene00006496
NDBlocus_tagCELE_C14A11.3
PanthergeneCAEEL|WormBase=WBGene00006496|UniProtKB=H2KYI7
familyPTHR22826
NCBIgene180571
RefSeqproteinNM_171641.6
NM_001129633.5
NM_171642.7
TREEFAMTREEFAM_IDTF332360
TrEMBLUniProtAccH2KYI7
H2KYI8
O02134
UniProt_GCRPUniProtAccH2KYI7
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:40WBPerson1971EventImportedInitial conversion from geneace
228 May 2004 13:57:59WBPerson1971EventAcquires_mergeWBGene00015749
318 Jul 2008 10:54:16WBPerson2970Name_changeCGC_namecgef-1
Other_nametag-150
413 Aug 2012 10:31:28WBPerson1849EventAcquires_mergeWBGene00194671
513 Aug 2012 10:31:28WBPerson1849EventAcquires_mergeWBGene00018887
613 Aug 2012 10:31:28WBPerson1849EventAcquires_mergeWBGene00018889
Acquires_mergeWBGene00015749
WBGene00194671
WBGene00018887
WBGene00018889
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classcgef
Allele (410)
StrainWBStrain00035827
WBStrain00040403
WBStrain00040404
WBStrain00040405
WBStrain00040406
RNASeq_FPKM (74)
GO_annotation00021671
00021672
00021673
00021674
00021675
00021676
00114153
Ortholog (66)
ParalogWBGene00006805Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00022391Caenorhabditis elegansFrom_analysisTreeFam
WBGene00015704Caenorhabditis elegansFrom_analysisTreeFam
WormBase-Compara
WBGene00006887Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00009337Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00010111Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00010776Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptioncgef-1 encodes a putative guanine nucleotide exchange factor (GEF) and positively regulates CDC-42 during asymmetric division in the embryo; cgef-1 also affects the localization of PAR proteins in the embryo; since cgef-1 mutants exhibit mild phenotypes, cgef-1 may function redundantly with other GEFs to regulate CDC-42 function; CGEF-1 expressed under germline regulatory control is enriched in the nucleoplasm and cell cortex and localizes to the cytoplasm.Paper_evidenceWBPaper00035488
Curator_confirmedWBPerson324
Date_last_updated04 Apr 2011 00:00:00
Automated_descriptionPredicted to enable guanyl-nucleotide exchange factor activity. Involved in protein localization. Located in cell cortex and nucleoplasm. Expressed in hermaphrodite gonad; neurons; somatic gonad precursor; and vulva. Is an ortholog of human MCF2 (MCF.2 cell line derived transforming sequence); MCF2L (MCF.2 cell line derived transforming sequence like); and MCF2L2 (MCF.2 cell line derived transforming sequence-like 2).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDSC14A11.3a
C14A11.3b
C14A11.3c
Corresponding_CDS_historyC14A11.3b:wp233
Corresponding_transcriptC14A11.3a.1
C14A11.3b.1
C14A11.3c.1
Other_sequence (12)
Associated_feature (29)
Experimental_infoRNAi_resultWBRNAi00048514Inferred_automaticallyRNAi_primary
WBRNAi00048515Inferred_automaticallyRNAi_primary
WBRNAi00086072Inferred_automaticallyRNAi_primary
WBRNAi00040462Inferred_automaticallyRNAi_primary
WBRNAi00010705Inferred_automaticallyRNAi_primary
WBRNAi00048512Inferred_automaticallyRNAi_primary
WBRNAi00028854Inferred_automaticallyRNAi_primary
WBRNAi00010704Inferred_automaticallyRNAi_primary
WBRNAi00015737Inferred_automaticallyRNAi_primary
WBRNAi00040461Inferred_automaticallyRNAi_primary
Expr_pattern (13)
Drives_construct (5)
Construct_productWBCnstr00013572
WBCnstr00017411
WBCnstr00037894
AntibodyWBAntibody00002109
Microarray_results (65)
Expression_cluster (179)
InteractionWBInteraction000427331
WBInteraction000504195
WBInteraction000504198
WBInteraction000504199
WBInteraction000504200
WBInteraction000519968
WBInteraction000551256
WBInteraction000556753
Map_infoMapXPosition-13.036Error0.227099
PositivePositive_cloneC14A11Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point4942
Pseudo_map_position
ReferenceWBPaper00032446
WBPaper00035488
WBPaper00038491
WBPaper00038565
WBPaper00040813
WBPaper00042051
WBPaper00051949
WBPaper00052002
WBPaper00053813
WBPaper00055090
WBPaper00056801
WBPaper00057743
WBPaper00060275
WBPaper00063093
WBPaper00066080
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene