WormBase Tree Display for Gene: WBGene00003246

WBGene00003246 SMap: S_parent: Sequence: R06B9
  Identity: Version: 2
    Name: CGC_name: mig-14 Paper_evidence: WBPaper00027609
          Person_evidence: WBPerson261
      Sequence_name: R06B9.6
      Molecular_name: R06B9.6
        R06B9.6.1
        CE34955
      Other_name: mom-3 Paper_evidence: WBPaper00027609
        let-553
        pvl-2
        CELE_R06B9.6 Accession_evidence: NDB BX284602
      Public_name: mig-14
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History (2)
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: mig
    Allele (434)
    Legacy_information: [Schlesinger A] phenotypes vary by allele. or78: zygotic defects: homozygotes slightly unc and display vulva defect (the gonad blows out through the vulva opening in young adults). Vulva defect supressed by lin-7 (blocking the vulva). 100% maternal-effect lethal, with 65% of embryos from homozygous mothers lacking endoderm and having excess mesoderm. mom-3 is required in P2 for endoderm induction and EMS spindle orientation.
      [Eisenmann DM] some vulval precursor cells (VPCs) fail to divide leading to fewer than 22 vulval cells formed and an Egl or Pvl (protruding vulva) phenotype. P12.p to P11.p cell fate transformation, abnormal gonad migration, poor male mating, slightly Unc.
      [Honigberg LA] QL descendants migrate to anterior, QR descendants and HSNs have shortened migrations, BDU posteriorly displaced. Mild Egl.
      [C.elegansII] mu71 : QL descendants migrate to anterior, QR descendants and HSNs have shortened migrations, BDU posteriorly displaced. Mild Egl. [CF]
      [Hodgkin JA ] e2617 is mut-2 induced. Hermaphrodites reach sterile adulthood, non-Unc, Evl, often rupture at L4 molt. Sperm present, many abnormal oocytes, Mel, variable arrest up to many cells, no morphogenesis. Many distorted eggs, never laid. More rupture at 25C. Males have sperm, fan, rays, very malformed tail, spicules absent or almost absent (slight sclerotization).
    Complementation_data: [Schlesinger A] does not complement mom-3 (zu21), let-553 (e2617), pvl-2 (ga62) or mig-14 (k124)
      [Eisenmann DM] ga62 fails to complement mig-14(mu71) for Egl phenotype. ga62 fails to complement mom-3(or78) for embryonic lethal phenotype.
    Strain: WBStrain00004822
      WBStrain00007272
      WBStrain00007433
    RNASeq_FPKM (74)
    GO_annotation (41)
    Ortholog (43)
    Structured_description: Concise_description: mig-14 encodes a novel, seven-transmembrane domain protein orthologous to Drosophila and human Wntless; mig-14 functions in many Wnt-related processes including endoderm induction and spindle orientation in the early embryo and later in vulval precursor cell fate specification; in the early embryo, mig-14 activity is required within Wnt-signaling cells, consistent with its proposed role in regulation of Wnt secretion; mig-14 also affects the migration of several different cell types during development including the Q neuroblasts along the anterior/posterior axis of the body, the distal tip cells in the gonad, the HSN, and the male linker cell; mig-14 is required for the expression of mab-5 which along with lin-39 regulates migration of cells in the Q lineages; mig-14 also acts independently of mab-5 to affect the final positioning of the Q descendants. Paper_evidence: WBPaper00002582
            WBPaper00002870
            WBPaper00003383
            WBPaper00003598
            WBPaper00003645
            WBPaper00004436
            WBPaper00027609
          Curator_confirmed: WBPerson1843
            WBPerson324
          Date_last_updated: 06 Dec 2006 00:00:00
      Automated_description: Predicted to enable Wnt-protein binding activity. Involved in several processes, including Wnt signaling pathway; embryonic morphogenesis; and left/right axis specification. Located in basolateral plasma membrane and cytoplasmic vesicle. Expressed in several structures, including CAN; anal region; intestinal muscle; tail hypodermis; and ventral nerve cord. Is an ortholog of human WLS (Wnt ligand secretion mediator). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0070473 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:30238)
  Molecular_info: Corresponding_CDS: R06B9.6
    Corresponding_transcript: R06B9.6.1
    Other_sequence (50)
    Associated_feature: WBsf990503
      WBsf222387
  Experimental_info: RNAi_result: WBRNAi00101489 Inferred_automatically: RNAi_primary
      WBRNAi00099143 Inferred_automatically: RNAi_primary
      WBRNAi00065890 Inferred_automatically: RNAi_primary
      WBRNAi00099142 Inferred_automatically: RNAi_primary
    Expr_pattern (12)
    Drives_construct: WBCnstr00005806
      WBCnstr00009253
      WBCnstr00009283
    Construct_product: WBCnstr00005806
      WBCnstr00007655
      WBCnstr00009186
      WBCnstr00009187
      WBCnstr00009253
      WBCnstr00009283
      WBCnstr00014995
      WBCnstr00038126
      WBCnstr00038423
      WBCnstr00039965
    Antibody: WBAntibody00002568
      WBAntibody00002569
    Microarray_results (14)
    Expression_cluster (130)
    Interaction (54)
    Anatomy_function: WBbtf0747
      WBbtf0778
      WBbtf0779
      WBbtf0780
      WBbtf0781
    WBProcess: WBbiopr:00000073
  Map_info: Map: II Position: 20.2541 Error: 0.053576
    Well_ordered
    Positive: Positive_clone: R06B9 Inferred_automatically: From sequence, transcript, pseudogene data
    Negative: Outside_rearr: mnDf106
        mnDf63
        mnDf66
        mnDf109
      Negative_clone: T05C12
    Mapping_data: Multi_point: 3561
        3562
        3563
        3303
        3500
        3836
        3791
        3792
        3790
      Pos_neg_data: 8672
        8673
        8674
        9153
        9154
        9155
        9156
    Landmark_gene
  Reference: WBPaper00002582
    WBPaper00002869
    WBPaper00002870
    WBPaper00003061
    WBPaper00003198
    WBPaper00003321
    WBPaper00003383
    WBPaper00003598
    WBPaper00003645
    WBPaper00003651
    WBPaper00003652
    WBPaper00003945
    WBPaper00004408
    WBPaper00004436
    WBPaper00004550
    WBPaper00005277
    WBPaper00005375
    WBPaper00005445
    WBPaper00005451
    WBPaper00006110
    WBPaper00006419
    WBPaper00010174
    WBPaper00010606
    WBPaper00010775
    WBPaper00017186
    WBPaper00017264
    WBPaper00017384
    WBPaper00017984
    WBPaper00018522
    WBPaper00018685
    WBPaper00021814
    WBPaper00022593
    WBPaper00022683
    WBPaper00027035
    WBPaper00027318
    WBPaper00027609
    WBPaper00027672
    WBPaper00028436
    WBPaper00028736
    WBPaper00030599
    WBPaper00031325
    WBPaper00031356
    WBPaper00031416
    WBPaper00031898
    WBPaper00032018
    WBPaper00032446
    WBPaper00032465
    WBPaper00033789
    WBPaper00035216
    WBPaper00036019
    WBPaper00036055
    WBPaper00036313
    WBPaper00036982
    WBPaper00037794
    WBPaper00037958
    WBPaper00038491
    WBPaper00038522
    WBPaper00038603
    WBPaper00038622
    WBPaper00039452
    WBPaper00040225
    WBPaper00040324
    WBPaper00040939
    WBPaper00045530
    WBPaper00045719
    WBPaper00047001
    WBPaper00047273
    WBPaper00048329
    WBPaper00049258
    WBPaper00050112
    WBPaper00051102
    WBPaper00052243
    WBPaper00053720
    WBPaper00054215
    WBPaper00055090
    WBPaper00055999
    WBPaper00056674
    WBPaper00059953
    WBPaper00062068
    WBPaper00064142
    WBPaper00065303
  Picture: WBPicture0000013083
    WBPicture0000013084
  Remark: Balanced by mnC1.
    not rescued by cosmid that rescues mig-5 ( pvl-2 shares phenotypes and general location with mig-5, but I was not able to obtain a mig-5 allele to do complementation test. Subsequent Df mapping suggests they are not the same gene).
    ga62 and mu71 fail to complement for a larval phenotype. ga62 and or78 fail to complement for an embryonic phenotype. ga62 has a low penetrance embryonic lethality. Therefore, ga62, mu71 and or78 may be alleles of the same gene (pvl-2/mig-14/mom-3) and ga62 and mu71 may retain more function than or78. One three factor cross located ga62 in the LGII cluster, however all subsequent data is consistent with LGIIR location of mig-14/mom-3.
  Method: Gene