WormBase Tree Display for Gene: WBGene00000421

WBGene00000421 SMap: S_parent: Sequence: C48B4
  Identity: Version: 1
    Name: CGC_name: ced-7 Person_evidence: WBPerson261
      Sequence_name: C48B4.4
      Molecular_name (13)
      Other_name: CELE_C48B4.4 Accession_evidence: NDB BX284603
      Public_name: ced-7
    DB_info: Database: AceView gene 3K660
        WormQTL gene WBGene00000421
        WormFlux gene WBGene00000421
        NDB locus_tag CELE_C48B4.4
        Panther gene CAEEL|WormBase=WBGene00000421|UniProtKB=P34358
          family PTHR19229
        NCBI gene 176352
        RefSeq protein NM_066714.5
            NM_001026054.4
            NM_001268083.3
            NM_001379863.2
        SwissProt UniProtAcc P34358
        TrEMBL UniProtAcc C0P274
        UniProt_GCRP UniProtAcc P34358
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ced
    Allele (150)
    Legacy_information: [C.elegansII] n1892 : programmed cell deaths abnormal, dying cells arrest at highly refractile stage; killer cells fail to engulf target cells; engulfment group A (ced-1,6,7); extensive maternal rescue; no gross phenotype. OA6: n1893, n1896, n1996,n1997, n1998, n2001, n2094.Cloned: encodes 191 kD protein, similarity to ABCtransporter proteins. [Ellis et al. 1991; MT; ZB]
    Strain (22)
    RNASeq_FPKM (74)
    GO_annotation (36)
    Ortholog (72)
    Paralog (4)
    Structured_description: Concise_description: ced-7 encodes an ATP binding cassette (ABC) transporter that is a member of the ABCA subfamily of transporter proteins; CED-7 activity is required in both apoptotic and phagocytic cells for engulfment of apoptotic cell corpses; in regulating apoptotic cell clearance, CED-7 functions upstream of CED-10/Rac, and together with CED-1 and CED-6, to mediate actin reorganization around the apoptotic cell corpse in the phagocytic cell; in regulating engulfment with CED-1 and CED-6, CED-7 acts in a pathway parallel to that of CED-2, CED-5, and CED-12; CED-7 localizes to the plasma membrane of many embryonic cells, but in larvae and adults is found in the amphid and phasmid sheath cells and the pharyngeal-intestinal valve; further, CED-7 is expressed in the Z2 and Z3 germline precursor cells and in the germline, except for sperm. Paper_evidence: WBPaper00003091
            WBPaper00005200
            WBPaper00025002
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 07 Mar 2006 00:00:00
      Automated_description: Predicted to enable ATP binding activity; ATPase-coupled transmembrane transporter activity; and lipid transporter activity. Involved in several processes, including engulfment of apoptotic cell; left/right axis specification; and phospholipid efflux. Located in plasma membrane. Expressed in Z2; Z3; germ line; neuronal sheath cell; and pharyngeal-intestinal valve. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: C48B4.4a
      C48B4.4b
      C48B4.4c
      C48B4.4d
    Corresponding_transcript: C48B4.4a.1
      C48B4.4a.2
      C48B4.4b.1
      C48B4.4c.1
      C48B4.4d.1
    Other_sequence (33)
    Associated_feature: WBsf651383
      WBsf651384
      WBsf667294
      WBsf667295
      WBsf1015629
      WBsf227320
      WBsf227321
      WBsf227322
      WBsf227323
      WBsf227324
  Experimental_info: RNAi_result: WBRNAi00029933 Inferred_automatically: RNAi_primary
      WBRNAi00042714 Inferred_automatically: RNAi_primary
      WBRNAi00006973 Inferred_automatically: RNAi_primary
      WBRNAi00042713 Inferred_automatically: RNAi_primary
      WBRNAi00066652 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1426
      Expr3316
      Expr1017941
      Expr1030237
      Expr1146706
      Expr2009851
      Expr2028091
    Drives_construct: WBCnstr00011312
      WBCnstr00037555
    Construct_product: WBCnstr00020626
      WBCnstr00037555
    Antibody: WBAntibody00000178
    Microarray_results (35)
    Expression_cluster (141)
    Interaction (61)
    Anatomy_function: WBbtf0061
    WBProcess: WBbiopr:00000013
      WBbiopr:00000014
      WBbiopr:00000015
  Map_info: Map: III Position: 0.651197 Error: 0.025749
    Well_ordered
    Positive: Inside_rearr: tnDf2
      Positive_clone: C29C3
        C48B4 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point (16)
      Pos_neg_data: 9446
        10531
        10535
  Reference: WBPaper00001438
    WBPaper00001487
    WBPaper00001491
    WBPaper00001642
    WBPaper00001728
    WBPaper00002172
    WBPaper00002212
    WBPaper00002388
    WBPaper00002422
    WBPaper00002437
    WBPaper00002592
    WBPaper00002867
    WBPaper00002891
    WBPaper00003074
    WBPaper00003090
    WBPaper00003091
    WBPaper00003301
    WBPaper00003451
    WBPaper00003914
    WBPaper00003957
    WBPaper00004218
    WBPaper00004462
    WBPaper00004503
    WBPaper00004564
    WBPaper00004751
    WBPaper00005196
    WBPaper00005200
    WBPaper00005291
    WBPaper00005538
    WBPaper00005555
    WBPaper00005787
    WBPaper00005857
    WBPaper00005874
    WBPaper00005898
    WBPaper00006212
    WBPaper00006383
    WBPaper00006404
    WBPaper00006421
    WBPaper00010011
    WBPaper00010012
    WBPaper00010169
    WBPaper00010266
    WBPaper00010312
    WBPaper00010361
    WBPaper00010405
    WBPaper00010416
    WBPaper00010710
    WBPaper00010787
    WBPaper00010840
    WBPaper00010959
    WBPaper00010999
    WBPaper00011043
    WBPaper00011045
    WBPaper00011183
    WBPaper00011213
    WBPaper00013208
    WBPaper00014255
    WBPaper00014938
    WBPaper00015090
    WBPaper00015205
    WBPaper00015476
    WBPaper00016901
    WBPaper00017179
    WBPaper00017692
    WBPaper00017887
    WBPaper00017888
    WBPaper00018248
    WBPaper00019400
    WBPaper00019412
    WBPaper00019503
    WBPaper00019514
    WBPaper00021687
    WBPaper00021737
    WBPaper00022142
    WBPaper00022289
    WBPaper00022326
    WBPaper00022509
    WBPaper00022829
    WBPaper00022913
    WBPaper00022914
    WBPaper00023027
    WBPaper00023145
    WBPaper00023393
    WBPaper00023566
    WBPaper00023796
    WBPaper00024057
    WBPaper00024058
    WBPaper00024253
    WBPaper00024474
    WBPaper00024942
    WBPaper00025002
    WBPaper00025454
    WBPaper00025757
    WBPaper00025999
    WBPaper00026487
    WBPaper00026772
    WBPaper00027291
    WBPaper00027296
    WBPaper00027398
    WBPaper00027644
    WBPaper00027659
    WBPaper00027834
    WBPaper00028352
    WBPaper00028961
    WBPaper00028966
    WBPaper00029005
    WBPaper00029018
    WBPaper00029228
    WBPaper00030417
    WBPaper00030424
    WBPaper00030738
    WBPaper00030766
    WBPaper00031470
    WBPaper00031484
    WBPaper00031498
    WBPaper00031730
    WBPaper00031731
    WBPaper00031753
    WBPaper00031805
    WBPaper00031858
    WBPaper00032003
    WBPaper00033098
    WBPaper00034773
    WBPaper00034913
    WBPaper00035284
    WBPaper00035888
    WBPaper00036252
    WBPaper00036351
    WBPaper00036352
    WBPaper00036496
    WBPaper00036497
    WBPaper00038317
    WBPaper00038491
    WBPaper00039499
    WBPaper00039521
    WBPaper00041220
    WBPaper00041221
    WBPaper00041869
    WBPaper00043671
    WBPaper00043684
    WBPaper00043689
    WBPaper00046300
    WBPaper00046306
    WBPaper00046916
    WBPaper00047460
    WBPaper00048010
    WBPaper00049245
    WBPaper00050403
    WBPaper00050421
    WBPaper00050503
    WBPaper00051950
    WBPaper00053323
    WBPaper00055000
    WBPaper00055090
    WBPaper00058433
    WBPaper00058439
    WBPaper00061024
    WBPaper00061198
    WBPaper00064325
    WBPaper00065354
  Method: Gene